Jan 1, 1981

Effect of ischemia on quantification of local cerebral glucose metabolic rate in man

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
R A HawkinsD E Kuhl

Abstract

The model for quantifying local cerebral glucose metabolic rates originally developed by Sokoloff et al. and modified by Phelps. Huang and co-workers was applied to humans with cerebral ischemia (i.e., stroke). Rate constants for fluorodeoxyglucose were measured in ischemic and nonischemic regions with position computed tomography. Using measured rate constants for ischemia, the model generate more accurate estimates of local cerebral glucose metabolism as compared to the use constants from normal young adults, because the local metabolic rate is significantly underestimated, and temporal instability of the model is observed when normal values are applied to ischemic regions. A method was also developed to test the stability of the local lumped constant. The estimates of the lumped constant showed no or only small variations between ischemic and nonischemic types. Thus, errors introduced in the calculated local cerebral glucose metabolism by inappropriate rate constants appear to be more significant than those caused by any potential change in the lumped constant in ischemia.

  • References30
  • Citations83
  • References30
  • Citations83

Citations

Mentioned in this Paper

Ischemia
Glucose Metabolism Disorders
Brain
X-Ray Computed Tomography
Tomography, Emission-Computed
Glucose, (beta-D)-Isomer
Etiology
Metabolic Rate
Glucose Metabolism
Cerebral Hemisphere Structure (Body Structure)

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