Effect of Ischemic Preconditioning on Marathon-Induced Changes in Serum Exerkine Levels and Inflammation

Frontiers in Physiology
Jan MieszkowskiJędrzej Antosiewicz

Abstract

Participation in a long-distance run, e.g., marathon or ultramarathon, continues to increase. One side effect of long-distance running is excessive inflammation manifested by the rise in inflammatory cytokine levels. We here aimed to elucidate the effects of 10-day ischemic preconditioning (IPC) training on marathon-induced inflammation and to evaluate the role of serum-stored iron in this process. The study involved 19 recreational runners taking part in a marathon. IPC training was performed in the course of four cycles, by inflating and deflating a blood pressure cuff at 5-min intervals (IPC group, n = 10); the control group underwent sham training (n = 9). The levels of inflammatory and others markers (FSTL-1, IL-6, IL-15, leptin, resistin, TIMP-1, OSM, and LIF) were measured before and 24 h after training; and before, immediately after, and 24 h and 7 day after the marathon. The 10-day IPC training increased serum leptin levels. IL-6, IL-10, FLST-1, and resistin levels were increased, while TIMP-1 levels were decreased in all runners after the marathon. The changes were significantly blunted in runners from the IPC group compared with the control group. Baseline serum iron levels correlated with IL-6 and FSTL-1 levels; ser...Continue Reading

References

Jan 1, 1992·European Journal of Applied Physiology and Occupational Physiology·R CandauJ R Lacour
Aug 12, 2000·International Journal of Sport Nutrition and Exercise Metabolism·N W ConstantiniB Falk
Oct 20, 2000·The Journal of Surgical Research·L GürkeM Heberer
Jun 4, 2002·Journal of Vascular Surgery·Denis W HarkinF Charles Campbell
Jun 27, 2002·The Journal of Biological Chemistry·Grazia AmbrosiniJaime Flores-Riveros
Aug 6, 2002·Cardiovascular Research·Karine LaudeVincent Richard
Feb 6, 2003·Medicine and Science in Sports and Exercise·Katsuhiko SuzukiKazuo Sugawara
Jul 15, 2003·American Journal of Physiology. Endocrinology and Metabolism·Adam SteensbergBente Klarlund Pedersen
Aug 12, 2004·Physiological Genomics·Igor E KonstantinovAndrew N Redington
May 3, 2005·The Journal of Clinical Investigation·Kathryn E Wellen, Gökhan S Hotamisligil
Mar 24, 2006·Brain, Behavior, and Immunity·David C NiemanJason D Morrow
Jan 2, 2007·Cytokine·Charlotte KellerBente Klarlund Pedersen
Dec 26, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Suzanne D ClutterRaphael Hirsch
Jan 10, 2009·Journal of Applied Physiology·Eric RullmanThomas Gustafsson
Nov 4, 2009·Scandinavian Journal of Medicine & Science in Sports·G HowatsonS A Howatson
Apr 28, 2010·Annual Review of Nutrition·Marianne Wessling-Resnick
Apr 30, 2011·Journal of Applied Physiology·Christa BroholmCamilla Scheele
May 28, 2011·Free Radical Biology & Medicine·Andzelika BorkowskaJedrzej Antosiewicz
Jun 10, 2011·American Journal of Physiology. Endocrinology and Metabolism·Pernille HojmanBente Klarlund Pedersen
Nov 19, 2011·Scandinavian Journal of Medicine & Science in Sports·C BerneckerM Halle
Dec 14, 2011·European Heart Journal·André La GercheDavid L Prior
Dec 31, 2011·Journal of Applied Physiology·Christina YfantiBente K Pedersen
Jul 31, 2012·Medicine and Science in Sports and Exercise·Sandra K Hunter, Alyssa A Stevens
Oct 20, 2012·Journal of Cardiovascular Medicine·Luciano CandilioDerek J Hausenloy
Aug 7, 2013·Basic Research in Cardiology·Sean M DavidsonDerek M Yellon
Oct 9, 2013·Proceedings of the National Academy of Sciences of the United States of America·Zheqing CaiGregg L Semenza
Dec 10, 2015·Sports Medicine·Anthony V IncognitoPhilip J Millar
Dec 15, 2015·Clinical Interventions in Aging·Jakub KortasJedrzej Antosiewicz
Nov 5, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sezin DagdevirenJason K Kim
Aug 24, 2017·Medicine and Science in Sports and Exercise·Alexander FranzMoritz Schumann
Jan 22, 2019·Journal of Strength and Conditioning Research·Beat KnechtlePantelis T Nikolaidis
Feb 20, 2019·American Journal of Physiology. Endocrinology and Metabolism·Pernille HojmanBente Klarlund Pedersen
Apr 6, 2019·Frontiers in Neuroscience·Malgorzata Halon-GolabekJedrzej Antosiewicz
Jul 25, 2019·Journal of Sport and Health Science·Maxime CaruDaniel Curnier
Nov 9, 2019·Journal of the International Society of Sports Nutrition·Nicholas B TillerLaurent Bannock
Apr 23, 2020·International Journal of Environmental Research and Public Health·Maja TomczykJędrzej Antosiewicz

❮ Previous
Next ❯

Citations

Aug 14, 2021·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·Bartłomiej NiespodzińskiJędrzej Antosiewicz
Aug 28, 2021·Genes·Kinga Humińska-LisowskaPaweł Cięszczyk

❮ Previous
Next ❯

Methods Mentioned

BETA
blood collection

Software Mentioned

GPower
Statistica

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Sports Medicine
J W LampeF S Apple
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
B KoneruA K Samanta
South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
S R GroblerR J Rossouw
Free Radical Biology & Medicine
Alexey ObolenskyMordechai Chevion
© 2021 Meta ULC. All rights reserved