PMID: 6169223Jul 1, 1981Paper

Effect of isobutylmethylxanthine and related drugs on the receptor response (ERG; a-wave) of the frog retina at various extracellular calcium concentrations

Zeitschrift Für Naturforschung. Section C: Biosciences
K H Leser

Abstract

Various drugs known or expected to increase the levels of cyclic nucleotides in cells were applied to isolated superfused frog retinae, and their influence on the aspartate-isolated a-wave was studied. Isobutylmethylxanthine (IBMX), triacetylguanosine (TAG), and dimethylaminopurine (DAMP) strongly influenced the responses elicited from dark-adapted retinae by flashes of light: With all three drugs the response amplitude was increased, and latency and time to peak were prolonged. If, on the other hand, the retinae were light-adapted by background light of various intensities, the drugs showed different effects on the response amplitude: IBMX either did not influence the amplitude at all or even caused a decrease (4 of 6 experiments), DAMP decreased the amplitude and TAG caused an increase of the amplitude in 2 of 3 experiments. But latency and time to peak were still prolonged by all three drugs. When dark-adapted retinae were superfused with IBMX or TAG Ringer solution and simultaneously calcium concentration was raised, different effects of calcium on the three measured parameters of the a-wave were observed: By increasing the extracellular calcium concentration the increase of the amplitude caused by drugs was reversed, down ...Continue Reading

Citations

Apr 11, 1986·Biochimica Et Biophysica Acta·K M KampsW J de Grip

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