Effect of isolation on brain monoamines and the behavior of mice in tests of exploration, locomotion, anxiety and behavioral 'despair'.

Pharmacology, Biochemistry, and Behavior
L A HilakiviR G Lister

Abstract

We have recently found that, besides an increase in aggression, isolation increases social interaction in NIH Swiss mice. In the present study the effect of isolation in other behavioral paradigms and their relation to brain monoamine concentrations were investigated. Mice, isolated for 0-20 days, were tested in the holeboard test of exploration and locomotor activity, the plus-maze test of anxiety, and Porsolt's swim test of behavioral 'despair.' Isolation reduced exploratory head-dipping, increased locomotor activity and increased the preference of mice for the open arms of the plus-maze. The immobility time in the swim test was shortened in mice isolated for 2 or 5 days, suggesting an improved ability to cope with stressful situations. Monoamine assays failed to show significant changes in the noradrenaline, dopamine, HVA, 5-HT or 5-HIAA contents in the amygdala, hypothalamus, hippocampus or brain stem. The results indicate that isolation of NIH Swiss mice for less than three weeks induces several behavioral changes, but is not particularly stressful.

References

Jan 15, 1975·Life Sciences·P Brain
Oct 14, 1975·Psychopharmacologia·S E File, A G Wardill
Jan 1, 1989·Behavioral and Neural Biology·M J Durcan, R G Lister
Jul 1, 1985·Biological Psychiatry·J A Jesberger, J S Richardson
Jan 1, 1987·Psychopharmacology·R G Lister
Jan 1, 1988·Psychopharmacology·R G Lister, L A Hilakivi
Mar 1, 1988·Pharmacology, Biochemistry, and Behavior·H Francès
Mar 1, 1986·Developmental Psychobiology·M L RiittinenG Johansson
Aug 3, 1973·Psychopharmacologia·L Valzelli
Jan 1, 1969·Psychopharmacologia·J H van Abeelen, H Strijbosch
Aug 1, 1968·Journal of Comparative and Physiological Psychology·W B Essman
Aug 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·S L Handley, S Mithani
Jan 1, 1984·Psychopharmacology·P Willner
Nov 1, 1962·Scientific American·H F HARLOW, M HARLOW

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Citations

Feb 1, 1994·Breast Cancer Research and Treatment·L Hilakivi-ClarkeM E Lippman
Jan 1, 1992·Psychopharmacology·L Hilakivi-Clarke, R G Lister
Sep 1, 1995·Psychopharmacology·S CabibS Puglisi-Allegra
Dec 21, 2004·Psychopharmacology·Benoit Petit-DemouliereMichel Bourin
May 1, 1992·Pharmacology, Biochemistry, and Behavior·L A Hilakivi-Clarke
Dec 23, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ming GuoDuo Chen
Sep 21, 2001·Physiology & Behavior·Y A BlednovR A Harris
Jun 19, 1998·Pharmacology, Biochemistry, and Behavior·O RilkeJ Oehler
May 30, 2001·Neuroscience and Biobehavioral Reviews·P Palanza
Feb 26, 1993·Behavioural Brain Research·M P Paulus, M A Geyer
Apr 12, 2003·Psychoneuroendocrinology·A BartolomucciS Parmigiani
Oct 31, 2002·The European Journal of Neuroscience·J HallerT F Freund
Jun 1, 1995·Alcoholism, Clinical and Experimental Research·L Hilakivi-Clarke, R Goldberg
Aug 5, 2005·Biological & Pharmaceutical Bulletin·Nguyen Thi Thu HuongKinzo Matsumoto
May 29, 2014·Physiology & Behavior·John L ShannonhouseCaurnel Morgan
Mar 25, 2014·Psychopharmacology·Giovanni BiggioMariangela Serra
Jun 9, 2007·Pharmacology & Therapeutics·Giovanni BiggioMariangela Serra
May 25, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Xiu Yan WeiChun Fu Wu
Sep 4, 2004·Genes, Brain, and Behavior·O Y VekovischevaE R Korpi
Jun 7, 2015·Behavioural Brain Research·Kaziya M LeeKaren K Szumlinski

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