PMID: 16612485Apr 14, 2006Paper

Effect of isopregnanolone on rapid tolerance to the anxiolytic effect of ethanol

Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina
Thaize Debatin, Adriana Dias Elpo Barbosa

Abstract

It has been shown that neurosteroids can either block or stimulate the development of chronic and rapid tolerance to the incoordination and hypothermia caused by ethanol consumption. The aim of the present study was to investigate the influence of isopregnanolone on the development of rapid tolerance to the anxiolytic effect of ethanol in mice. Male Swiss mice were pretreated with isopregnanolone (0.05, 0.10 or 0.20 mg/kg) 30 min before administration of ethanol (1.5 g/kg). Twenty-four hours later, all animals we tested using the plus-maze apparatus. The first experiment defined the doses of ethanol that did or did not induce rapid tolerance to the anxiolytic effect of ethanol. In the second, the influence of pretreatment of mice with isopregnanolone (0.05, 0.10 or 0.20 mg/kg) on rapid tolerance to ethanol (1.5 g/kg) was studied. The results show that pretreatment with isopregnanolone interfered with the development of rapid tolerance to the anxiolytic effect of ethanol.

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Citations

Sep 8, 2007·Physiology & Behavior·María E PallarésRodolfo A Cutrera
Jul 28, 2011·Alcoholism, Clinical and Experimental Research·Amul J SakharkarSubhash C Pandey
Aug 23, 2011·The International Journal of Neuropsychopharmacology·Daniela F FukushiroRoberto Frussa-Filho
Dec 28, 2018·The International Journal of Neuropsychopharmacology·Tiffani D M BerkelSubhash C Pandey
Jan 24, 2017·Alcoholism, Clinical and Experimental Research·Tiffani D M Berkel, Subhash C Pandey
Feb 26, 2021·Pharmacology, Biochemistry, and Behavior·Sophie K ElvigLeandro F Vendruscolo

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