Effect of itopride on gastric emptying in longstanding diabetes mellitus

Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
J E StevensK L Jones

Abstract

Delayed gastric emptying (GE) occurs in 30-50% of patients with longstanding type 1 or 2 diabetes, and represents a major cause of morbidity. Current therapeutic options are limited. We aimed at evaluating the effects of itopride on GE in patients with longstanding diabetes. Twenty-five patients (20 type 1, 5 type 2; 10 males, 15 females; mean age 45.2 +/- 2.7 years; body mass index 27.5 +/- 0.9 kg m(-2); duration of diabetes 20.2 +/- 2.4 years) were enrolled in a double-blind, placebo-controlled, randomized, crossover trial. Subjects received both itopride (200 mg) and placebo t.i.d. for 7 days, with a washout of 7-14 days. GE (scintigraphy), blood glucose (glucometer) and upper gastrointestinal (GI) symptoms (questionnaire) were measured following each treatment period. The test meal comprised 100 g ground beef (99mTc-sulphur colloid) and 150 mL of 10% dextrose [67Ga-ethylenediaminetetraacetic acid (EDTA)]. There was a slight trend for itopride to accelerate both solid (P = 0.09) and liquid (P = 0.09) GE. With itopride treatment, the emptying of both solids and liquids tended to be more accelerated, as the emptying with placebo was slower (solids: r = 0.39, P = 0.057; liquids: r = 0.44, P < 0.03). Twelve (48%) patients had de...Continue Reading

References

Jan 1, 1991·European Journal of Nuclear Medicine·M HorowitzD J Shearman
Apr 12, 1990·The New England Journal of Medicine·J JanssensR Bouillon
Jan 1, 1985·Digestive Diseases and Sciences·M HorowitzD J Shearman
Oct 2, 1982·British Medical Journal·D J Ewing, B F Clarke
Apr 15, 2000·Journal of Diabetes and Its Complications·A J Evans, A J Krentz
Feb 20, 2003·The American Journal of Gastroenterology·Nicholas J Talley
May 2, 2003·The Journal of Pharmacology and Experimental Therapeutics·Tadashi TsubouchiYuji Iwanaga
Nov 27, 2004·Otolaryngologic Clinics of North America·Kristin A Seiberling, David B Conley
May 19, 2005·The Journal of Clinical Endocrinology and Metabolism·Antonietta RussoKaren L Jones
Feb 24, 2006·The New England Journal of Medicine·Gerald HoltmannChristopher Parow
May 17, 2006·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M HorowitzN W Read
Feb 16, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R S ChoungA R Zinsmeister

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Citations

Jun 13, 2012·Current Gastroenterology Reports·Reza A HejaziIrene Sarosiek
Nov 10, 2012·World Journal of Gastroenterology : WJG·Hyun Chul LimHyojin Park
Sep 24, 2014·Current Treatment Options in Gastroenterology·Jan Tack, Christophe Vanormelingen
Feb 24, 2009·Gastrointestinal Endoscopy Clinics of North America·Reza A Hejazi, Richard W McCallum
Jan 6, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Young-Min ParkJae-Hyuck Cho
Nov 23, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J E StevensK L Jones
Nov 19, 2010·Alimentary Pharmacology & Therapeutics·E ScarpelliniJ Tack
May 15, 2013·Expert Opinion on Pharmacotherapy·Julie E StevensMichael Horowitz
Feb 5, 2009·Expert Opinion on Pharmacotherapy·Savio C Reddymasu, Richard W McCallum
Jun 6, 2009·Drugs·Jing MaMichael Horowitz
Apr 9, 2009·Expert Review of Gastroenterology & Hepatology·Joan KhooMichael Horowitz
Nov 23, 2013·Biomolecules & Therapeutics·Yong Sam Kwon, Miwon Son
Mar 1, 2011·Obstetric Medicine·N AchongM D'emden
May 24, 2017·Gut and Liver·Nanlong Liu, Thomas Abell
May 4, 2021·United European Gastroenterology Journal·Jolien ScholUNKNOWN ESNM Gastroparesis Consensus Group
Aug 17, 2021·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Jolien ScholUNKNOWN ESNM Gastroparesis Consensus Group

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