Effect of IV contrast medium on renal function in oncologic patients undergoing CT in ICU

AJR. American Journal of Roentgenology
Chaan S NgJoshua A Samuels

Abstract

The purpose of our study was to assess the effect of IV contrast medium administered at CT on serum creatinine in an oncologic ICU population and to determine which of the variables before CT are most associated with renal function after administration of contrast material. We retrospectively reviewed 3,848 patient admissions to an oncology ICU. The following matched comparisons were undertaken: contrast-enhanced CT versus unenhanced CT and CT (with or without contrast medium) versus no CT. Matching criteria included age, sex, baseline serum creatinine, and severity of illness (modified sequential organ failure assessment [mSOFA] score). No patients with creatinine > 2.0 mg/dL received contrast material. Groups were compared using a rank sum test. Factors influencing creatinine after administration of contrast material were evaluated by multiple regression analysis. Parallel analyses using estimated glomerular filtration rate (eGFR) also were performed. No significant difference was found in absolute change in creatinine between matched contrast-enhanced CT and unenhanced CT groups (n = 81), with mean (95% CI) creatinine rises after CT of 0.25 (0.04-0.46) and 0.11 (0.04-0.18) mg/dL, respectively. Similarly, for matched CT versu...Continue Reading

References

Jan 20, 1992·The Medical Journal of Australia·G Rilsfeldt
Sep 2, 1991·The Medical Journal of Australia·C A HellerR F Heller
Nov 1, 1988·Critical Care Medicine·P I MenasheJ E Gottlieb
Feb 7, 2003·The New England Journal of Medicine·Peter AspelinUNKNOWN Nephrotoxicity in High-Risk Patients Study of Iso-Osmolar and Low-Osmolar Non-Ionic Contrast Media Study Investigators
Aug 2, 2003·The British Journal of Radiology·H S Thomsen, S K Morcos
Nov 18, 2004·AJR. American Journal of Roentgenology·Tadhg G Gleeson, Sudi Bulugahapitiya
Apr 14, 2006·Kidney International. Supplement·R W Katzberg, C Haller
Jun 3, 2006·Intensive Care Medicine·Jan Willem HavemanMaarten W N Nijsten
Mar 3, 2007·Critical Care : the Official Journal of the Critical Care Forum·Ravindra L MehtaUNKNOWN Acute Kidney Injury Network
Oct 15, 2008·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Jay P Heiken
Feb 24, 2009·AJR. American Journal of Roentgenology·Richard J BruceMyron A Pozniak
Apr 24, 2010·Health Informatics Journal·Joseph L NatesKristen J Price

❮ Previous
Next ❯

Citations

Mar 26, 2014·AJR. American Journal of Roentgenology·Matthew S DavenportJames H Ellis
Jan 31, 2013·Radiology·Robert J McDonaldDavid F Kallmes
Mar 25, 2014·European Journal of Radiology·Manal AzzouzHenrik S Thomsen
May 14, 2014·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Mukta D AgrawalDushyant V Sahani
Oct 1, 2016·Journal of the American Society of Nephrology : JASN·Emilee Wilhelm-LeenGlenn Chertow
Oct 15, 2014·Current Opinion in Critical Care·Wim VandenbergheEric A J Hoste
Oct 29, 2013·Critical Care Medicine·Stephan Ehrmann, Karim Lakhal
Jan 18, 2013·Critical Care Medicine·Stephan EhrmannKarim Lakhal
Oct 17, 2017·Oncotarget·Jolanta MałyszkoJacek Małyszko
Jul 11, 2019·Critical Care : the Official Journal of the Critical Care Forum·Yuya GotoShin Nunomiya
Feb 19, 2017·Intensive Care Medicine·Jennifer S McDonaldKianoush Kashani
Nov 11, 2020·Critical Care : the Official Journal of the Critical Care Forum·Karim LakhalVincent Robert-Edan
Aug 5, 2011·Current Opinion in Urology

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.