Mar 1, 1976

Effect of izadrin, inderal and netalid on the periodic activity of the rabbit myometrium

Farmakologiia i toksikologiia
G S Koroza, A N Kudrin


The contractility of an isolated rabbit uterus was studied. It was found that when used in low concentrations (1.10(-9)-1.10(-7) g/ml) isoprenaline, while stimulating the beta-adrenoreceptors of the uterus, inhibits its contractions, whereas in high concentrations (1.10(6)-1.10(-5) g/ml) it is capable of intensifying uterine contractions owing to stimulation of the uterine alpha-adrenoreceptors. Dihydroergotoxin (1.10(-6) g/ml), a blocking agent of alpha-adrenoreceptors, averts and eliminates the stimulating effect of isoprenaline on the uterus. Propranolol and netalide, blocking agents of the beta-adrenoreceptors, abolish the already developed depressing action of isoprenaline on the contractile activity of the uterus, but fail to prevent this effect with their preliminary application.

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Mentioned in this Paper

Entire Uterus
Neoplasm of Uncertain or Unknown Behavior of Uterus
Contraction (Finding)
Malignant Neoplasm of Myometrium
Entire Myometrium
Drug Interactions

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