PMID: 3384363Jun 1, 1988Paper

Effect of jejunal infusion of bile acids on small bowel transit and fasting jejunal motility in man

Gut
R PenaginiP G Frost

Abstract

The effect of jejunal infusion of glycochenodeoxycholic acid and glycocholic acid on small bowel transit time, fasting jejunal motility and serum bile acid concentrations was investigated in groups of five to six healthy subjects. Glycochenodeoxycholic acid at a concentration of 15 mmol/l (total amount: 5 mmol) and glycocholic acid 15 mmol/l (total amount: 5 mmol), both with lecithin 2.5 mmol/l, delayed (p less than 0.02) small bowel transit when compared with a bile acid free infusion [158.3 (12.5) min v 111.7 (17.6) min and 103.3 (21.8) min v 70.0 (14.9) min], inhibited (p less than 0.01 and p less than 0.05 respectively) the percentage duration of pressure activity of phase 2 [13.1 (1.8)% v 28.1 (3.4)% and 29.2 (5.5)% v 34.9 (3.9)%], but did not change duration of migrating motor complex, or of its phases. Glycochenodeoxycholic acid 10 mmol/l (total amount: 3.3 mmol), either with or without lecithin, did not delay small bowel transit significantly [145.0 (13.2) min v 115.0 (19.5) and 90.0 (11.7) min v 84.0 (8.3)]. When bile acids were infused, serum bile acid curves were similar to those obtained after a liquid meal and the peak serum bile acid concentration occurred 33.7 (6.6) min before (p less than 0.001) completion of sm...Continue Reading

References

Feb 1, 1979·Digestive Diseases and Sciences·J R MalageladaW H Summerskill
Nov 1, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·U AbshagenH Rennekamp
Jan 1, 1988·Digestive Diseases and Sciences·R PenaginiD B Silk
Aug 1, 1971·The Journal of Clinical Investigation·H S MekjianA F Hofmann
Jul 1, 1966·The American Journal of Digestive Diseases·J S Fordtran, T W Locklear

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Citations

Jun 14, 2002·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Isabelle Le Blanc-LouvryP Ducrotté
Oct 3, 2002·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·N A M Van OoteghemG P Van Berge-Henegouwen
Jan 1, 1992·Scandinavian Journal of Gastroenterology. Supplement·A J van TilburgM van Blankenstein
Nov 1, 1994·Scandinavian Journal of Gastroenterology·T HallgrenL Hultén
Mar 20, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·D P PooleC U Corvera
Sep 24, 2014·Inflammatory Bowel Diseases·Libor Vítek
May 31, 2017·Journal of Neurogastroenterology and Motility·Nam Hee KimYeun-Ho Joung
Feb 19, 2013·The Journal of Clinical Endocrinology and Metabolism·Tongzhi WuChristopher K Rayner
Feb 1, 1992·Journal of Clinical Pharmacology·K TsutsumiS Nakano
Aug 14, 2020·Physiological Reviews·Alessia PerinoKristina Schoonjans
Aug 28, 2021·International Journal of Molecular Sciences·Mariusz A Bromke, Małgorzata Krzystek-Korpacka
Nov 11, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Stephen Joseph KeelySimona Elisa Carbone

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