PMID: 38409Apr 30, 1979

Effect of kainic acid injections and other brain lesions on vasoactive intestinal peptide (VIP)-stimulated formation of cAMP in rat brain

Naunyn-Schmiedeberg's Archives of Pharmacology
M QuikL L Iversen

Abstract

In rat striatal slices, both intrastriatal kainic acid injection, which destroys striatal neurones, and intranigral injection of 6-hydroxydopamine (6-OHDA), which leads to a degeneration of dopamine nerve terminals in the striatum, reduced vasoactive intestinal peptide (VIP)-induced cAMP accumulation by approximately 60%. Cortical ablation, which leads to degeneration of cortico-striatal fibres, had no effect on striatal VIP-induced cAMP formation. Knife cut lesions transecting the stria terminalis, which destroy afferent fibres to the amygdala, decreased the VIP-induced increase in cAMP in amygdala slices by 40%, while kainic acid injection into the amygdala had no effect. Kainic acid injection into several other brain regions, including hippocampus, cortex and hypothalamus also failed to affect the VIP-elicited increase in cAMP in slices, despite reductions in choline acetyl-transferase, glutamate decarboxylase, cyclic nucleotide phosphodiesterase and basal levels of cAMP. The results of a study of the effects of various VIP fragments on cAMP stimulation in striatal and cortical slices suggests that the entire sequence of VIP is necessary for full activity. The results suggest that VIP may be involved in neuromodulation or ne...Continue Reading

References

Mar 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·J McCullochL Edvinsson
Sep 1, 1986·British Journal of Pharmacology·K D Bhoola, S Pay
Jan 1, 1981·Neurosurgical Review·H W Pia

Citations

May 27, 1977·Brain Research·R Schwarcz, J T Coyle
Oct 2, 1976·Lancet·A GiachettiS I Said
Oct 7, 1977·Science·R M Herndon, J T Coyle
Aug 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·A GiachettiF C Koniges
Nov 30, 1979·Brain Research·P C EmsonO B Schaffalitzky de Muckadell
Apr 1, 1978·Canadian Journal of Physiology and Pharmacology·J W PhillisS I Said
Dec 1, 1978·Journal of Neurochemistry·J Fahrenkrug, O B Schaffalitzky de Muckadell
Jun 30, 1978·Brain Research·S M WuertheleK E Moore
Sep 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·L I LarssonJ R Rehfeld
Nov 1, 1977·FEBS Letters·M Deschodt-LanckmanJ Christophe
Dec 17, 1976·Brain Research·E G McGeerP L McGeer
Jan 19, 1971·Biochemistry·W J Thompson, M M Appleman
Feb 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·M BodanszkyS I Said
Jan 1, 1973·Journal of Comparative and Physiological Psychology·G Paxinos, D Bindra

Related Concepts

Striatonigral Degeneration, Infantile (Disorder)
Biochemical Pathway
Choline
Cortex Bone Disorders
Abnormal Degeneration
Adrenal Cortex Diseases
Neostriatum
Phosphoric diester hydrolase
Bulla
Brain

Related Feeds

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.