PMID: 11932057Apr 5, 2002Paper

Effect of kappa opioid agonists on visceral nociception induced by uterine cervical distension in rats

Pain
Andreas Sandner-KieslingJames C Eisenach

Abstract

Although uterine distension in rats results in an escape reflex, there exists no model of uterine cervical distension (UCD), the pain stimulus during the first stage of labor. The aims of this study were to develop such a model in virgin rats and to test whether peripherally restricted kappa opioid receptor (KOR) agonists (ADL 10-0101, ADL 10-0102, ADL 10-0116) inhibit responses to UCD. Under intravenous (i.v.) pentobarbital and alpha-chloralose anesthesia, fine metal rods were inserted in both uterine cervical osses through a small midline laparotomy. UCD was performed by manual separation of the rods (25-100 g). Single-unit afferent responses in hypogastric nerve or reflex rectus abdominis electromyographic (EMG) activity were determined before and after i.v. KOR agonists. UCD resulted in a stimulus-dependent increase in single-unit afferent activity. Units could be characterized as low threshold (mean threshold 6.6+/-2.7 g), or high threshold (mean threshold 55+/-8.8 g); all were C fibers, all responded to topical bradykinin. ADL 10-0116 (10 mg/kg) reduced the afferent response to UCD. Reflex EMG response occurred over a distension force range of 25-100 g, unaffected by i.v. saline. All three KOR agonists produced a dose-dep...Continue Reading

References

Jan 1, 1988·Journal of Neurophysiology·K J BerkleyY Sato
Jan 1, 1986·Annals of the New York Academy of Sciences·B R Komisaruk, B Whipple
Oct 1, 1984·Quarterly Journal of Experimental Physiology : an International Journal of the Physiological Society·D F Cottrell
Jun 1, 1983·Pflügers Archiv : European journal of physiology·P HauptW Kohler
Jul 1, 1996·Physiology & Behavior·R Cueva-RolónB R Komisaruk
Sep 12, 1996·Journal of the Autonomic Nervous System·L E GómezR Cueva-Rolón
May 1, 1997·Cell and Tissue Research·E B HaaseL P Schramm
Jun 17, 1998·Neuroscience Letters·U WesselmannM A Giamberardino
Sep 25, 1998·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·T A Bowdle
Mar 6, 1999·Pain·J N SenguptaG F Gebhart

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Citations

Nov 13, 2003·Peptides·Richard J Bodnar, Maria M Hadjimarkou
Jan 20, 2010·The Clinical Journal of Pain·Todd W Vanderah
Oct 24, 2006·Anesthesia and Analgesia·Chuanyao TongJames C Eisenach
Dec 10, 2009·Medicine and Science in Sports and Exercise·Josué Fernández-CarneroPascal Madeleine
Jan 23, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Jonathan W BoydSteven M Yellon
Jul 1, 2013·Sexual Medicine Reviews·Lesley MarsonUrsula Wesselmann
Dec 1, 2009·International Journal of Obstetric Anesthesia·L Z WangX Y Chang
Mar 31, 2004·British Journal of Pharmacology·Pierre J-M Rivière
Apr 30, 2014·Acta Obstetricia Et Gynecologica Scandinavica·Lars Arendt-NielsenAsbjørn M Drewes
Apr 2, 2003·Expert Opinion on Therapeutic Targets·Hai-Ying M Cheng, Josef M Penninger
May 24, 2008·Anesthesiology·Chuanyao TongJames C Eisenach
Oct 6, 2006·Current Opinion in Anaesthesiology·Andreas Sandner-Kiesling, Carsten Bantel
Feb 26, 2005·Anesthesiology·Lawrence C Tsen
Oct 3, 2002·Anesthesiology·Andreas Sandner-Kiesling, James C Eisenach
Mar 19, 2005·Journal of Neurophysiology·Baogang LiuChuanyao Tong
Aug 2, 2003·Nature Medicine·Christoph SteinHalina Machelska
Apr 4, 2021·European Journal of Pharmacology·Qi XuXinzhong Chen

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