Effect of KCNQ1 G229D mutation on cardiac pumping efficacy and reentrant dynamics in ventricles: Computational study

International Journal for Numerical Methods in Biomedical Engineering
Ana Rahma YuniartiKi Moo Lim

Abstract

There is growing interest in genetic arrhythmia since mutations in gene which encodes the ion channel underlie numerous arrhythmias. Hasegawa et al reported that G229D mutation in KCNQ1 underlies atrial fibrillation due to significant shortening of action potential duration (APD) in atrial cells. Here, we predicted whether KCNQ1 G229D mutation affects ventricular fibrillation generation, although it shortens APD slightly compared with the atrial cell. We analyzed the effects of G229D mutation on electrical and mechanical ventricle behaviors (not considered in previous studies). We compared action potential shapes under wild-type and mutant conditions. Electrical wave propagations through ventricles were analyzed during sinus rhythm and reentrant conditions. IKs enhancement due to G229D mutation shortened the APD in the ventricular cells (6%, 0.3%, and 8% for endo, M, and epi-cells, respectively). The shortened APD contributed to 7% shortening of QT intervals, 29% shortening of wavelengths, 20% decrease in intraventricular pressure, and increase in end-systolic volume 17%, end-diastolic volume 7%, and end-diastolic pressure 11%, which further resulted in reduction in stroke volume as well as cardiac output (28%), ejection fracti...Continue Reading

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Citations

Mar 16, 2019·Biomedical Engineering Online·Nida DusturiaKi Moo Lim
Apr 25, 2020·Computational and Mathematical Methods in Medicine·Da Un JeongKi Moo Lim
Feb 26, 2020·Medical & Biological Engineering & Computing·Aulia Khamas HeikhmakhtiarKi Moo Lim
Jul 28, 2020·Journal of Korean Medical Science·Aulia Khamas HeikhmakhtiarKi Moo Lim

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