Effect of kerosene and its soot on the chrysotile-mediated toxicity to the rat alveolar macrophages

Environmental Research
J M ArifQ Rahman

Abstract

In order to examine the pulmonary toxicity of kerosene oil and its combustion product (soot) in asbestos-exposed rats, various biochemical and chemical parameters were assayed. Treatment of rats with a single intratracheal dose of chrysotile asbestos (5 mg) and kerosene (50 microliters) or its soot (5 mg) in combination led to an increased number of pulmonary alveolar macrophages (PAM), elevated levels of hydrogen peroxide, and thiobarbituric acid-reacting substances, alterations in the activities of primary (glutathione peroxidase and catalase) and secondary (glutathione reductase and glucose-6-phosphate dehydrogenase) endogenous antioxidant enzymes, and depletion in the levels of glutathione in PAM compared to the chrysotile, kerosene, or soot alone. These changes may indicate the generation of oxidative stress in the macrophages. The resulting oxidative stress may be subsequently critical in collapsing the cellular membrane, which may change the cell membrane permeability and may also damage the phagolysosomal membrane, thereby releasing the membrane bound enzymes as indicated by an increased leakage of intracellular acid phosphatase and lactate dehydrogenase. The injury to macrophages may trigger events that lead to lung fi...Continue Reading

References

Aug 23, 1976·Biochemical and Biophysical Research Communications·R A Lawrence, R F Burk
Jan 1, 1992·Free Radical Biology & Medicine·D W KampS A Weitzman
Jan 1, 1991·Lung·A M Cantin, R Bégin
Aug 1, 1989·The American Review of Respiratory Disease·J E Heffner, J E Repine
Jan 1, 1985·Journal of Free Radicals in Biology & Medicine·S D AustC E Thomas
Jan 1, 1988·Experimental Lung Research·J L WrightA Churg
May 1, 1988·Mutation Research·R Menghini
Jan 1, 1987·Archives of Environmental Health·M Noa, J Illnait
Apr 1, 1984·The Biochemical Journal·B Halliwell, J M Gutteridge
Jul 1, 1981·Chest·R F HendersonE G Damon
Dec 1, 1994·Environmental Health Perspectives·T R QuinlanB T Mossman
Dec 1, 1994·Environmental Health Perspectives·V Vallyathan
Oct 1, 1994·Environmental Health Perspectives·J M ArifQ Rahman
Mar 1, 1965·Archives of Biochemistry and Biophysics·N ZAHEERP S KRISHNAN

❮ Previous
Next ❯

Citations

Sep 1, 2012·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Nicholas L LamMichael N Bates
Jan 1, 2007·Indian Journal of Occupational and Environmental Medicine·F A AnsariI Ahmad
May 31, 2003·Human & Experimental Toxicology·Mohamed AmeenQamar Rahman
Sep 9, 2018·Occupational and Environmental Medicine·Jessica L ElfJonathan E Golub

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.