Effect of ketanserin, a new blocking agent of the 5-HT2 receptor, on airway responsiveness in asthma

Allergy
Mario CazzolaG D'Amato

Abstract

Most of the antihypertensive drugs have a liability for adverse effects in asthma. Since there are few available data on the effect of ketanserin, a new antihypertensive drug which is a type-2 serotonin receptor antagonist, on human respiratory function, we have tested whether this drug can modify bronchial hyperresponsiveness to methacholine in asthmatic patients. The protective effect of intravenous ketanserin (0.14 mg/kg) was small, but significant.

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Related Concepts

Respiratory Physiology
Bronchial Provocation Tests
R-41,468
Adverse Effects
Dose-Response Relationship, Immunologic
Asthma
Antihypertensive Agents
Lobar Bronchus Structure
Methacholine
Serotonin Antagonists

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