PMID: 11323536Apr 27, 2001Paper

Effect of ketoprofen on muscle function and sEMG activity after eccentric exercise

Medicine and Science in Sports and Exercise
Stephen P SayersG Kamen

Abstract

This study examined whether ketoprofen, a nonsteroidal anti-inflammatory drug, attenuated muscle soreness (SOR), improved maximal isometric force (MIF) recovery, and/or altered myoelectric activity after high-force eccentric exercise. 48 subjects were randomly assigned to one of four groups: CON: no exercise/no drug (N = 12); PLA: exercise + placebo (N = 12); TRT-100: exercise + 100 mg oral ketoprofen (N = 12); and TRT-25: exercise + 25 mg oral ketoprofen (N = 12). PLA, TRT-100, and TRT-25 were administered in a double-blind fashion. Baseline measurements of SOR, MIF, and surface electromyographic (EMG) amplitude were taken, and PLA, TRT-100, and TRT-25 performed 50 maximal eccentric contractions of the elbow flexors; 36 h later, subjects reporting moderate soreness were given ketoprofen or placebo and SOR measures were taken hourly for 8 h. EMG amplitude was assessed during MIF before dosing and again 8 h later and during submaximal contractions of 5%, 10%, and 20% of MIF before dosing and hourly for 8 h. Eccentric exercise increased myoelectric activity during submaximal force measurements in PLA, TRT-100, and TRT-25 in all conditions. Ketoprofen had no effect on reducing this increase in EMG activity. Ketoprofen attenuated p...Continue Reading

Citations

May 17, 2003·Medicine and Science in Sports and Exercise·Stephen P Sayers, Pricilla M Clarkson
May 3, 2007·Medicine and Science in Sports and Exercise·Monica J HubalPriscilla M Clarkson
Mar 28, 2012·Scandinavian Journal of Medicine & Science in Sports·A L MackeyM Kjaer
Feb 7, 2013·The FEBS Journal·Marielle SaclierBénédicte Chazaud
Mar 30, 2017·The American Journal of Sports Medicine·Kimberly M MorelliGordon L Warren
Oct 30, 2004·Medicine and Science in Sports and Exercise·Vincent MartinLoïc Perrod
Jun 16, 2009·Scandinavian Journal of Medicine & Science in Sports·G PaulsenT Raastad
May 21, 2008·Sports Medicine·Glyn Howatson, Ken A van Someren
Nov 9, 2019·Journal of the International Society of Sports Nutrition·Nicholas B TillerLaurent Bannock
Dec 3, 2009·Medicine and Science in Sports and Exercise·Robert D HyldahlPriscilla M Clarkson
Dec 17, 2016·Antioxidants·Maria Carmen Gomez-CabreraLi Li Ji
May 17, 2003·Medicine and Science in Sports and Exercise·Stephen P SayersPriscilla M Clarkson
Aug 3, 2006·Journal of Sports Sciences·Timothy W TourvilleBrian V Reed
Apr 1, 2016·Medicine and Science in Sports and Exercise·José Rafael LópezJosé Antonio Adams
Apr 29, 2010·The Physician and Sportsmedicine·Stuart J Warden
Jun 12, 2010·Journal of Bodywork and Movement Therapies·Denise CurtisCarolyn McMakin

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