PMID: 2098914Dec 1, 1990Paper

Effect of ketotifen on the ultrastructure of the erythrocytic stages of Plasmodium yoelii

The Southeast Asian Journal of Tropical Medicine and Public Health
H M Cao, X Q Pan

Abstract

The effect on the morphology of Plasmodium yoelii of ketotifen treatment was different from that of chloroquine and other antimalarial drugs. Following administration of a low dosage of ketotifen, the parasite first developed a multilamellate pellicular complex which resembled a medullary sheath and then developed vacuoles and cavitations. The development of large multilamellate whorls consisting of a pellicular structure enclosing cytoplasm was the typical change which occurred.

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