DOI: 10.1101/499889Dec 19, 2018Paper

Effect of KNL1 on the proliferation and apoptosis of colorectal cancer cells

BioRxiv : the Preprint Server for Biology
Tianliang BaiBinghui Li


Background: To identify the expression of KNL1 in colorectal tumor tissues and to clarify the function of this gene on the proliferation capability of colorectal cancer cells. Methods: Thirty-six pairs of colorectal tumor and normal tissue were collected and subjected to quantitative PCR analysis. KNL1 was under-expressed using lentiviral transfection, and the function of KNL1 was evaluated by proliferation assay, colony formation and apoptosis assay. Results: KNL1 was highly expressed in colorectal tumor tissues. KNL1 downregulation inhibited colorectal cancer cell proliferation and promoted apoptosis. Conclusions: KNL1 plays an effective role in decreasing the apoptosis and promoting the proliferation of colorectal cancer cells.

Related Concepts

Colorectal Neoplasms
Tumor Cells, Malignant
Cell Proliferation
Protein Expression
CASC5 protein, human
Colorectal Cancer
Real-Time Polymerase Chain Reaction

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