PMID: 9542688May 30, 1998Paper

Effect of Korean red ginseng on the rabbit corpus cavernosal smooth muscle

International Journal of Impotence Research
Y D ChoiH K Choi

Abstract

The extracts of Korean red ginseng (EKG) is a complex mixture containing ginsenosides, polysaccharides, and several other products. Animal experiments have shown that the intravenous administration of extract of ginseng reduces blood pressure. Recently, it has been reported that ginseng has a relaxing effect on vascular smooth muscle and that the relaxation is associated with nitric oxide (NO) released from the vascular endothelium. The present study was undertaken to investigate the effects of EKG on isolated rabbit corpus cavernosal smooth muscle for evaluation of the possibility of developing EKG as an pharmacoerecting agent. Strips of rabbit corpus cavernosum were mounted in organ chambers to measure isometric tension. On the precontracted muscle strip with phenylephrine (PHE; 5 x 10(-6) M), EKG began to exert a relaxing effect at the concentration of 1 mg/ml and the maximal relaxation effect was reached at 40 mg/ml in a dose-dependent manner. EKG was inhibited significantly by endothelial disruption and by pretreatment with methylene blue, pyrogallol, L-NNA or atropine. EKG partially inhibited the PHE (5 x 10(-6) M) induced contraction up to 45.67% of the control in a dose-dependent fashion. EKG decreased basal tension as ...Continue Reading

Citations

Aug 5, 2003·Pharmacology, Biochemistry, and Behavior·David O Kennedy, Andrew B Scholey
Nov 27, 2009·International Journal of Impotence Research·H-J XiaoX Gao
Jun 24, 2011·International Journal of Impotence Research·H H SungS W Lee
Aug 28, 2003·Clinical and Experimental Pharmacology & Physiology·Francis I Achike, Chiu-Yin Kwan
Jul 5, 2006·Biological & Pharmaceutical Bulletin·Sang-Won ParkSun-Mee Lee
Oct 18, 2016·Journal of Ginseng Research·Ho Sung LeeJi Hoon Jeong
Jun 5, 2007·Endocrinology and Metabolism Clinics of North America·Ronald Tamler, Jeffrey I Mechanick
Aug 30, 2008·British Journal of Clinical Pharmacology·Dai-Ja JangEdzard Ernst
May 5, 2004·The Urologic Clinics of North America·Mark A MoyadUNKNOWN Sexual Medicine Society Nutraceutical Committee
Sep 24, 1999·The Journal of Urology·Y D ChoiH K Choi
Oct 29, 2004·International Journal of Impotence Research·R ThurairajaR Persad
Aug 2, 2000·The American Journal of Clinical Nutrition·L R Bucci
Apr 20, 2021·The Cochrane Database of Systematic Reviews·Hye Won LeeDu Geon Moon

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