PMID: 698378Sep 1, 1978Paper

Effect of Krebs cycle intermediates on the blood supply and energy metabolism of ischemic myocardium

Biulleten' eksperimental'noĭ biologii i meditsiny
Kh D Baĭramkulov, V V Gatsura

Abstract

The influence of d-ketoglutarate and succinate in acute experiments on dogs was studied by the following parameters: collateral coronary circulation (CCC) of the ischemic myocardium, systemic arterial pressure, and the content of lactic, pyruvic acids, and glucose in the blood flowing from the ischemic zone. alpha-ketoglutarate (6 mg/kg intracoronary and 60 mg/kg intravenously) proved to produce a positive effect on CCC and the contractile activity of the myocardium. Intravenous injection of alpha-ketoglutarate (12 mg/kg) and succinate (100 mg/kg) decreased significantly the consumption of glucose by the ischemic myocardium which rose after the ligation. In comparison with alpha-ketoglutarate, all doses of succinate were more effective as a factor of preventing the increase of lactic acid in the blood flowing from the ischemic zone. Thus, definite doses of alpha-ketoglutarate and succinate could be used for pharmacological correction of CCC and energy supply of the ischemic myocardium.

References

May 1, 1972·Journal of Bioenergetics·V P Skulachev

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Citations

Jan 31, 1998·Biulleten' eksperimental'noĭ biologii i meditsiny·L D Luk'ianova

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