PMID: 16639878Apr 28, 2006Paper

Effect of L-ascorbic acid on nickel-induced alterations in serum lipid profiles and liver histopathology in rats

Journal of Basic and Clinical Physiology and Pharmacology
Kusal K DasJeevan G Ambekar

Abstract

Nickel exposure greatly depletes intracellular ascorbate and alters ascorbate-cholesterol metabolism. We studied the effect of the simultaneous oral treatment with L-ascorbic acid (50 mg/100 g body weight (BW) and nickel sulfate (2.0 mg/100 g BW, i.p) on nickelinduced changes in serum lipid profiles and liver histopathology. Nickel-treated rats showed a significant increase in serum low-density lipoprotein-cholesterol, total cholesterol, triglycerides, and a significant decrease in serum high-density lipoprotein-cholesterol. In the liver, nickel sulfate caused a loss of normal architecture, fatty changes, extensive vacuolization in hepatocytes, eccentric nuclei, and Kupffer cell hypertrophy. Simultaneous administration of L-ascorbic acid with nickel sulfate improved both the lipid profile and liver impairments when compared with rats receiving nickel sulfate only. The results indicate that L-ascorbic acid is beneficial in preventing nickel-induced lipid alterations and hepatocellular damage.

References

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Sep 3, 2002·Environmental Health Perspectives·Kusal K Das, Shakuntala Dasgupta
Jul 24, 2004·The Journal of Biological Chemistry·Konstantin SalnikowKazimierz S Kasprzak
Oct 13, 2004·Journal of Andrology·Kodipura Doreswamy Muralidhara
Apr 5, 2005·Journal of Basic and Clinical Physiology and Pharmacology·Kusal K Das, Swastika N Das

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Citations

Apr 10, 2013·Asian Pacific Journal of Tropical Biomedicine·Shaheen A ManiyarKusal K Das
Jan 1, 2011·Journal of Basic and Clinical Physiology and Pharmacology·Kusal K DasSwastika N Das
Jan 14, 2009·International Journal of Environmental Research and Public Health·Amrita Das GuptaKusal K Das
Aug 11, 2006·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Kusal K DasJeevan G Ambekar
Oct 28, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Najla HfaiedhFrançoise Croute
Jun 24, 2017·Journal of Cellular Biochemistry·Kanwal RehmanMuhammad Sajid Hamid Akash
Apr 3, 2008·Journal of Basic and Clinical Physiology and Pharmacology·Amrita Das GuptaKusal K Das
Nov 26, 2008·Journal of Basic and Clinical Physiology and Pharmacology·Swati N TikareKusal K Das
Dec 6, 2019·Endocrine, Metabolic & Immune Disorders Drug Targets·Swastika DasKusal K Das
Oct 19, 2010·European Journal of Pharmacology·Leelavinothan Pari, Kasinathan Amudha
May 24, 2011·Chemico-biological Interactions·K Amudha, L Pari

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