Effect of L-carnitine on liver cell membranes in ethanol-intoxicated rats

Chemico-biological Interactions
Izabela DobrzynskaZbigniew Figaszewski

Abstract

Ethanol intoxication is characterized by changes in cell metabolism which alter the structure and function of cell membrane components, including phospholipids and integral membrane proteins. The interaction of food nutrients with ethanol may modulate alcohol toxicity. One such compound is l-carnitine (l-3-hydroxy-4-N,N,N-trimethylaminobutyrate), which is also an antioxidant. Here we investigate l-carnitine as an antioxidant and assess its effect on the composition and electrical charge of liver cell membranes in ethanol-intoxicated rats. Qualitative and quantitative phospholipid composition and the presence of integral membrane proteins were determined by high performance liquid chromatography (HPLC). Electrophoresis was used to determine the surface charge density of the rat liver cell membranes. Ethanol increased phospholipid levels and altered the level of integral proteins as determined by decreased phenylalanine (Phe), cysteine (Cys) and lysine (Lys). Ethanol significantly enhanced changes in the surface charge density of the liver cell membranes. l-Carnitine administration to ethanol-intoxicated rats significantly protects phospholipids and proteins against oxidative modifications. Therefore, the beneficial effect of l-c...Continue Reading

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Citations

Nov 25, 2011·The Journal of Membrane Biology·Aneta D PetelskaZbigniew A Figaszewski
Apr 25, 2012·The Journal of Membrane Biology·Barbara Szachowicz-PetelskaZbigniew Figaszewski
Dec 12, 2013·Journal of Gastroenterology and Hepatology·Shima HatamkhaniSirous Jafari
Nov 29, 2013·Journal of Toxicology and Environmental Health. Part a·Ewa AmbrożewiczElżbieta Skrzydlewska
May 7, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alessandra DurazzoAntonello Santini
Feb 13, 2021·Alcoholism, Clinical and Experimental Research·A Brianne BotaKumanan Wilson

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