Effect of L-Carnitine on QT Dispersion in Patients With Acute Coronary Syndrome

Kardiologiia
M G GleserE I Astashkin

Abstract

to evaluate the impact of L-carnitine on the dispersion of the interval QT (AQTc) in patients with acute coronary syndrome (ACS). In a prospective, randomized, double-blind, placebo-controlled study included 58 patients with ACS who have not had surgery (29 in group receiving L-carnitine, and 29 in the placebo group). L-carnitine was administered intravenously during the first 3 days to 2 g, 2 times a day, with 4 on the 15th day (or until discharge, if it occurred earlier)--for 1 g of 2 times per day. AQTc defined as the difference between the maximum and minimum duration of the QT interval in each of the 12 standard ECG leads surface--ECG (ΔQT = QTmax-QTmin) on the 1st, 2, 3, 5, 7 and 12-14th day. Compared groups did not differ in their baseline characteristics. Under the influence of L-carnitine reduction ΔQTc was more pronounced and significantly decreased since the 1st day of treatment. Thus, the group of patients treated with L-carnitine, ΔQTc decreased from 79.9 ± 19.9 to 60.4 ± 17.5 ms (p < 0.0001) and amounted to 12-14-th day of treatment 41.1 ± 7.6 ms (p < 0.0001) in the placebo group-respectively from 74.9 ± 23.2 to 68.3 ± 22.4 ms (p = 0.277) and 53.5 ± 15.0 ms (p = 0.0003). In the group of patients treated with L-car...Continue Reading

Citations

Mar 9, 2019·Recent Patents on Drug Delivery & Formulation·Sergei V Jargin
May 16, 2019·Terapevticheskiĭ arkhiv·Zh M SizovaA A Makhova

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