Effect of L-carnitine upon ammonia tolerance test in cirrhotic patients

Advances in Experimental Medicine and Biology
J A del OlmoM Bixquert

Abstract

In a group of liver cirrhosis (LC) patients subjected to a rectal ammonium overload test, the effect of L-carnitine on ammoniemia and on the type A numerical connection and star clock psychomotor tests has been evaluated. On comparing 40 LC patients given L-carnitine with 40 control cirrhotics given a placebo, no significant differences were observed in ammonium levels after performing the overload test in both groups. However, on studying the patients with the greatest liver involvement, those given L-carnitine showed smaller elevations in ammoniemia and better responses to the psychometric tests than those receiving the placebo. The results obtained emphasize the need to continue testing the effect of L-carnitine using either similar tests or carrying out long-term evaluations to determine its protective effect in the appearance of hepatic encephalopathy, perhaps even including its evaluation in the treatment of established encephalopathy.

Citations

Jun 4, 2010·Drugs·Paula V PhongsamranAngela Rosenblatt
Mar 29, 2001·Postgraduate Medicine·S Abou-Assi, Z R Vlahcevic
Feb 14, 2007·Alimentary Pharmacology & Therapeutics·N M Bass
Aug 18, 2000·Nutrition Reviews·S D LiA Hagerty
Feb 14, 2008·Digestive Diseases and Sciences·Nathan J Shores, Emmet B Keeffe
Aug 9, 2012·Clinical Pharmacology and Therapeutics·C F Rose
Jan 1, 1996·Life Sciences·S Krähenbühl

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