Effect of L-histidine and chlorcyclizine on apomorphine-induced climbing behaviour and methamphetamine stereotypy in mice

European Journal of Pharmacology
V V JoshiA G Chandorkar

Abstract

Pretreatment with L-histidine (850 and 1000 mh/kg, i.p.), a precursor of brain histamine, and chlorcyclizine (25 and 50 mg/kg, i.p.), a H1-receptor blocker, failed to modify apomorphine-induced climbing behaviour in mice. In contrast, pretreatment with L-histidine (850 and 1000 mg/kg) was found to antagonise methamphetamine stereotypy while pretreatment with chlorcyclizine (25 mg/kg) was found to potentiate methamphetamine-induced stereotypy in mice. The results suggest that drugs which influence central histaminergic mechanisms are effective only in modifying the behaviour induced by the indirectly acting DA agonist methamphetamine and fail to modify the behaviour induced by apomorphine, a directly acting DA agonist.

References

Aug 15, 1975·Life Sciences·J C Schwartz
Jan 21, 1977·European Journal of Pharmacology·H Ozawa, T Miyauchi
May 15, 1977·European Journal of Pharmacology·N Subramanian, A H Mulder
Feb 1, 1972·Journal of Neurochemistry·K M Taylor, S H Snyder

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Citations

Feb 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·P ProtaisJ C Schwartz
Nov 19, 1982·European Journal of Pharmacology·B CostallR J Naylor
Jan 1, 1990·Neuroscience and Biobehavioral Reviews·J P HustonR K Schwarting
Aug 5, 2000·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·C Ito
Oct 31, 1996·Annals of the New York Academy of Sciences·C ItoT Watanabe
Nov 16, 2004·Annals of the New York Academy of Sciences·Kentaro IwabuchiKazuhiko Yanai
Jan 15, 2014·Neuron·Lissandra Castellan BaldanChristopher Pittenger
Mar 12, 2016·Drug Target Insights·Junichi KitanakaMotohiko Takemura

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