PMID: 43281Oct 1, 1979

Effect of L-histidine pretreatment on methamphetamine induced sterotyped behaviour in rats

Indian Journal of Physiology and Pharmacology
M P MuleyA G Chandorkar

Abstract

Pretreatment with L-histidine precursor of histamine was found to delay the onset, shorten the duration and decrease the intensity of stereotyped behaviour induced by methamphetamine while chlorcylizine a H1 receptor blocker was found not only to potentiate methamphetamine induced sterotyped behaviour but also to block the inhibitory effect of L-histidine on methamphetamine stereotypy. Our results indicate that the central histaminergic system by exerting a modulatory influence on the striatal dopaminergic system may influence the functioning of the extrapyramidal motor system.

Related Concepts

Dose-Response Relationship, Drug
Drug Interactions
Histidine
Madrine
Piperazines
Stereotyped Behavior

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