Effect of L-NAME on nitric oxide and gastrointestinal motility alterations in cirrhotic rats

World Journal of Gastroenterology : WJG
Xin WangDai-Ming Fan

Abstract

To investigate the effect of L-NAME on nitric oxide and gastrointestinal motility alterations in cirrhotic rats. Rats with cirrhosis induced by carbon tetrachloride were randomly divided into two groups, one n =13 receiving 0.5mg.kg(-1) per day of N(G)-nitro-L-arginine methyl ester (L-NAME), a nitric oxide synthase inhibitor, for 10 days, whereas the other group (n =13) and control (n =10) rats were administrated the same volume of 9g.L(-1) saline. Half gastric emptying time and 2h residual rate were measured by SPECT, using (99m)Tc-DTPA-labeled barium sulfate as test meal. Gastrointestinal transition time was recorded simultaneously. Serum concentration of nitric oxide (NO) was determined by the kinetic cadmium reduction and colorimetric methods. Immunohistochemical SABC method was used to observe the expression and distribution of three types of nitric oxide synthase (NOS) isoforms in the rat gastrointestinal tract. Western blot was used to detect expression of gastrointestinal NOS isoforms. Half gastric emptying time and trans-gastrointestinal time were significantly prolonged(124.0 +/- 26.4 min; 33.7 +/- 8.9 min; 72.1 +/- 15.3 min; P<0.01), (12.4 +/- 0.5h; 9.5 +/- 0.3h; 8.2 +/- 0.8h; P<0.01), 2h residual rate was raised in ...Continue Reading

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Citations

Jan 13, 2004·World Journal of Gastroenterology : WJG·Jun-Wang XuGui-Ping Xu
May 23, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·P KuoC K Rayner
Aug 15, 2003·World Journal of Gastroenterology : WJG·Ning-Li ChaiXi-Lin Dong
Jun 7, 2017·Gastroenterology Research and Practice·Eleni TheocharidouDavid Patch

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