PMID: 108729Mar 22, 1979

Effect of L-tryptophan on the acquisition of tolerance to ethanol-induced motor impairment and hypothermia

A Dûng LêA E LeBlanc


Rats were rendered tolerant to ethanol by daily gavage of 4--5 g/kg. The degree of motor impairment on the moving belt test and of hypothermia after i.p. test doses of ethanol was measured prior to and at various times during the chronic treatment, to assess the rates of tolerance development. L-Tryptophan (75 mg/kg twice daily) was administered chronically to elevate brain serotonin level. This treatment did not alter the motor impairment or hypothermia produced by the initial test doses of ethanol (2.0 and 2.5 g/kg respectively). However, the development of tolerance to both the motor impairment and hypothermia effects of ethanol was accelerated in the tryptophan-treated rats. This finding complements our earlier observations that depletion of 5-HT with p-CPA slows down tolerance. Blood ethanol measurements at 20 min (motor impairment) or 90 min (hypothermia) after the administration of the test dose reveal no significant difference between the control and tryptophan-treated rats, suggesting that tryptophan did not influence the metabolism of ethanol. This finding supports the hypothesis that brain serotonin modulates the development of tolerance to ethanol.


Aug 1, 1977·Canadian Journal of Physiology and Pharmacology·D FrankelH Kalant
Jan 1, 1977·Advances in Experimental Medicine and Biology·J M Khanna, H Kalant
Sep 25, 1978·Life Sciences·A Wirz-JusticeH Feer
Jan 1, 1977·Advances in Experimental Medicine and Biology·B TabakoffP L Hoffman
Dec 1, 1978·Canadian Journal of Physiology and Pharmacology·G I SunaharaL Grupp
Jul 28, 1976·Psychopharmacology·A E LeBlancR J Gibbins
Sep 30, 1976·Nature·R F Ritzmann, B Tabakoff
Feb 1, 1976·Pharmacology, Biochemistry, and Behavior·A E LeBlancH Kalant
May 21, 1973·Psychopharmacologia·A E LeBlancH Kalant
Sep 1, 1971·Psychophysiology·F A Holloway, O A Parsons
Oct 1, 1968·Journal of Neurochemistry·A T Moir, D Eccleston
Jul 1, 1968·Canadian Journal of Physiology and Pharmacology·A E LeBlanc
Jun 1, 1966·Journal of Comparative and Physiological Psychology·J E Koepke, K H Pribram


Feb 1, 1980·Psychopharmacology·A D LêA E LeBlanc
Jun 4, 1982·European Journal of Pharmacology·A D LêJ M Khanna
Dec 1, 1984·Physiology & Behavior·L Mattucci-Schiavone, A P Ferko
Jan 1, 1986·Physiology & Behavior·L Mattucci-Schiavone, A P Ferko
Jul 1, 1981·Pharmacology, Biochemistry, and Behavior·M B Bass, D Lester
Apr 1, 1986·Pharmacology, Biochemistry, and Behavior·C L Melchior, B Tabakoff
Jan 1, 1983·Pharmacology & Therapeutics·H Kalant, A D Lê
Jan 1, 1988·Pharmacology & Therapeutics·L A Pohorecky, J Brick
Jan 1, 1981·Progress in Neuro-psychopharmacology·J M KhannaA E LeBlanc
Jan 1, 1981·Progress in Neuro-psychopharmacology·T Nabeshima, I K Ho
May 1, 1987·Alcohol·E Romm, A C Collins
Dec 1, 1991·Alcoholism, Clinical and Experimental Research·H FisherG C Wagner
Jan 1, 1988·Neurochemistry International·H OllatS Parvez
Jan 1, 1980·Pharmacology, Biochemistry, and Behavior·N Rangaraj, H Kalant
Jan 1, 1980·Acta Psychiatrica Scandinavica. Supplementum·J M KhannaA E LeBlanc
Jan 1, 1980·Acta Psychiatrica Scandinavica. Supplementum·J M KhannaA E LeBlanc

Related Concepts

Drug Tolerance
Motor Skills
Rats, Laboratory

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