PMID: 6990780May 1, 1980Paper

Effect of lactate and palmitate on substrate utilization of isolated rat soleus

The American Journal of Physiology
F J Pearce, R J Connett

Abstract

The effects of exogenous lactate and palmitate on the metabolism of rat soleus muscle were studied. In the presence of glucose and insulin, the addition of 8 mM lactate resulted in a decrease in the oxidation of both glucose and other substrates. Lactate accounted for 70% of the oxygen consumption under these conditions. Glycogen accumulation and the incorporation of exogenous palmitate into triglycerides were stimulated by lactate addition, whereas the utilization of exogenous glycerol was depressed. The addition of 1 mM palmitate in either the presence or absence of lactate resulted in an inhibition of both glycolysis and the utilization of exogenous glucose. The results are discussed in terms of the effect of lactate levels on recovery from exercise.

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Citations

Jan 22, 1998·The American Journal of Physiology·C PaganoR Vettor
Jul 7, 2001·American Journal of Physiology. Endocrinology and Metabolism·V K KaushikN B Ruderman
Nov 2, 2002·The Journal of Physiology·Benjamin F MillerGeorge A Brooks
Dec 7, 2007·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Arie RotsteinBareket Falk
Aug 26, 2004·American Journal of Physiology. Endocrinology and Metabolism·Jill A FattorGeorge A Brooks
Nov 7, 2019·The Journal of Biological Chemistry·James R KrycerDavid E James
Oct 12, 2002·American Journal of Physiology. Endocrinology and Metabolism·Benjamin F MillerGeorge A Brooks
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Jul 12, 2002·American Journal of Physiology. Endocrinology and Metabolism·Cheol S ChoiJang H Youn
Mar 19, 2019·PloS One·Synthia H MellonOwen M Wolkowitz
Nov 6, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ching-Ping Chih, Eugene L Roberts
Feb 2, 2021·The Journal of Biological Chemistry·James R KrycerDavid E James
Apr 16, 2021·PeerJ·José Miguel Rodríguez-LópezIgnacio Fernández-Fígares
Nov 12, 1982·Biochimica Et Biophysica Acta·J F Glatz, J H Veerkamp

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