Effect of Lactobacillus casei on the Production of Pro-Inflammatory Markers in Streptozotocin-Induced Diabetic Rats

Probiotics and Antimicrobial Proteins
A ZarfeshaniM S A Mutalib

Abstract

It has been demonstrated that probiotic supplementation has positive effects in several murine models of disease through influences on host immune responses. This study examined the effect of Lactobacillus casei strain Shirota (L. casei Shirota) on the blood glucose, C-reactive protein (CRP), Interleukin-6 (IL-6), Interleukin-4 (IL-4), and body weight among STZ-induced diabetic rats. Diabetes mellitus was induced by streptozotocin (STZ, 50 mg/kg BW) in male Sprague-Dawley rats. Streptozotocin caused a significant increase in the blood glucose levels, CRP, and IL-6. L. casei Shirota supplementation lowered the CRP and IL-6 levels but had no significant effect on the blood glucose levels, body weight, or IL-4. Inflammation was determined histologically. The presence of the innate immune cells was not detectable in the liver of L. casei Shirota-treated hyperglycemic rats. The probiotic L. casei Shirota significantly lowered blood levels of pro-inflammatory cytokines (IL-6, CRP) and neutrophils in diabetic rats, showing a lower risk of diabetes mellitus and its complications.

References

Jan 1, 1991·Biotherapy·C Grunfeld, K R Feingold
Oct 15, 1993·Clinica Chimica Acta; International Journal of Clinical Chemistry·M A CrookJ C Pickup
Feb 1, 1994·Immunology Today·H Baumann, J Gauldie
Aug 1, 1997·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·T MatsuzakiT Yokokura
Sep 17, 1998·The Journal of Clinical Investigation·H E ThomasT W Kay
Jan 5, 2000·Journal of Diabetes and Its Complications·M Rodríguez-Morán, F Guerrero-Romero
Apr 5, 2001·American Journal of Physiology. Endocrinology and Metabolism·P A KernG Ranganathan
Jul 24, 2001·JAMA : the Journal of the American Medical Association·A D PradhanP M Ridker
Jul 27, 2001·Alimentary Pharmacology & Therapeutics·L O'MahonyJ K Collins
Jun 8, 2002·Urologia Internationalis·Yasuo OhashiYoshio Aso
Mar 20, 2003·Current Diabetes Reports·Paresh Dandona
Jul 5, 2003·Bioscience, Biotechnology, and Biochemistry·Mihoko TabuchiAkiyoshi Hosono
May 11, 2004·World Journal of Gastroenterology : WJG·Hai-Hong CuiXue-Qing Chen
May 19, 2004·Hypertension·Ishwarlal JialalSenthil K Venugopal
Mar 1, 2005·Trends in Biotechnology·Itamar RazYaakov Naparstek
Apr 14, 2005·International Journal of Cancer. Journal International Du Cancer·Hideki IshikawaTadao Kakizoe
Jul 14, 2005·Annual Review of Nutrition·U SinghI Jialal
Oct 4, 2005·Journal of the American College of Cardiology·Joseph F MaloufVirend K Somers
Oct 11, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Lorraine MarnellTerry W Du Clos
Jan 28, 2006·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Keiichi IshidaMasaru Miyazaki
Apr 7, 2006·Journal of Cellular Biochemistry·William C ChoKevin K Yue
May 17, 2007·Acta Cirúrgica Brasileira·Mardem Machado de SouzaDiana Borges Dock-Nascimento
Feb 19, 2008·British Journal of Clinical Pharmacology·Dimitrios Damaskos, George Kolios
Feb 27, 2008·World Journal of Gastroenterology : WJG·Riina-A KekkonenIlkka Julkunen

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Citations

May 13, 2015·Diabetes/metabolism Research and Reviews·Elham RazmpooshParvin Mirmiran
Mar 15, 2013·International Journal of Food Sciences and Nutrition·Somayyeh FirouziKamaruddin Nor Azmi
May 26, 2017·São Paulo Medical Journal = Revista Paulista De Medicina·Maryam MiraghajaniReza Ghiasvand
Jul 26, 2018·European Journal of Nutrition·Sebastian TorresPaola Gauffin-Cano

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