Effect of Lactobacillus casei on the Pharmacokinetics of Amiodarone in Male Wistar Rats

European Journal of Drug Metabolism and Pharmacokinetics
Zuzana MatuskovaEva Anzenbacherova

Abstract

The probiotic bacterium Escherichia coli strain Nissle 1917 has previously been shown to alter the pharmacokinetics of amiodarone. The aim of this study was to determine whether the probiotic bacterium Lactobacillus casei produces similar alterations in amiodarone disposition. A suspension of live probiotic bacteria L. casei strain DN-114 001 (1.5 × 10(9) CFU/dose; probiotic pre-treated group) or a saline solution (control group) was administered directly into the stomach of male Wistar rats (N = 30 in each group) by oral gavage daily for 7 consecutive days. On the eighth day, all rats (N = 60) were given a single oral dose of an amiodarone hydrochloride suspension (model drug; 50 mg/kg). The concentrations of amiodarone and of its main metabolite N-desethylamiodarone were determined in rat plasma by high-performance liquid chromatography. Comparison of the pharmacokinetics of amiodarone in the control group and probiotic pre-treated group revealed that the peak plasma concentration of amiodarone was delayed by >2 h in the probiotic pre-treated group. The plasma level of N-desethylamiodarone was unchanged in the probiotic pre-medicated group and its pharmacokinetic parameters were not altered. The slower absorption of amiodaron...Continue Reading

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Citations

Feb 23, 2019·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Lenka JourovaEva Anzenbacherova
Feb 6, 2020·Frontiers in Cellular and Infection Microbiology·Grégoire WieërsPatrice D Cani
Mar 7, 2020·Drug Metabolism and Personalized Therapy·Daniel J SeligJeffrey R Livezey
Jun 7, 2019·Trends in Pharmacological Sciences·Reese Hitchings, Libusha Kelly

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