PMID: 16648901May 2, 2006Paper

Effect of Lactobacillus delbrueckii on cholesterol metabolism in germ-free mice and on atherogenesis in apolipoprotein E knock-out mice

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
L R PortugalJ I Alvarez-Leite

Abstract

Elevated blood cholesterol is an important risk factor associated with atherosclerosis and coronary heart disease. Several studies have reported a decrease in serum cholesterol during the consumption of large doses of fermented dairy products or lactobacillus strains. The proposed mechanism for this effect is the removal or assimilation of intestinal cholesterol by the bacteria, reducing cholesterol absorption. Although this effect was demonstrated in vitro, its relevance in vivo is still controversial. Furthermore, few studies have investigated the role of lactobacilli in atherogenesis. The aim of the present study was to determine the effect of Lactobacillus delbrueckii on cholesterol metabolism in germ-free mice and the possible hypocholesterolemic and antiatherogenic action of these bacteria using atherosclerosis-prone apolipoprotein E (apo E) knock-out (KO) mice. For this purpose, Swiss/NIH germ-free mice were monoassociated with L. delbrueckii and fed a hypercholesterolemic diet for four weeks. In addition, apo E KO mice were fed a normal chow diet and treated with L. delbrueckii for 6 weeks. There was a reduction in cholesterol excretion in germ-free mice, which was not associated with changes in blood or liver cholester...Continue Reading

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Citations

Nov 17, 2011·European Journal of Nutrition·Juliana L GonçalvesJacqueline I Alvarez-Leite
Apr 10, 2010·Journal of Atherosclerosis and Thrombosis·Renata StepankovaHelena Tlaskalova-Hogenova
Dec 3, 2016·Nature Reviews. Cardiology·Annika Lindskog Jonsson, Fredrik Bäckhed
Jan 15, 2017·Molecular Nutrition & Food Research·Rima H MistryUwe J F Tietge
Jan 1, 2013·Bioscience of Microbiota, Food and Health·Yasunori YonejimaYoshiro Mori
May 15, 2020·Molecular Nutrition & Food Research·Rima H MistryUwe J F Tietge
Nov 11, 2019·Reviews in Endocrine & Metabolic Disorders·Marc Schoeler, Robert Caesar
Nov 30, 2019·BMC Biology·Tiphaine Le RoyPhilippe Lesnik

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