PMID: 38663Aug 1, 1979

Effect of lactulose, neomycin and antacid on colonic pH recorded continuously with an implanted electrode

The American Journal of Gastroenterology
N S MannR L Martin

Abstract

Colonic pH was continuously monitored by a pH electrode implanted in the transverse colon of rats over a 24-hour period. Lactulose significantly reduced the colonic pH to 5.37 +/- .39 from a fasting value of 6.77 +/- .75. Pretreatment with neomycin or concomitant use of a nonabsorbable antacid prevented lactulose-induced reduction in the colonic pH. The clinical implication of the study is that combined use of lactulose with neomycin or high doses of non-absorbable antacids in the treatment of chronic portasystemic encephalopathy may be undesirable.

Related Concepts

Implantable Stimulation Electrodes
Taenia Coli
Normase
Neomycin Palmitate
Disaccharides
Antacids
Brain Damage, Chronic
Fulminant Hepatic Failure With Cerebral Edema
Hydrogen-Ion Concentration
Philadelphia Chromosome

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