Effect of lamotrigine on EEG paroxysmal abnormalities and background activity: a computerized analysis

British Journal of Clinical Pharmacology
M G MarcianiG Bernardi

Abstract

1. Little information is available about the action of lamotrigine (LTG) on EEG paroxysmal abnormalities and background activity. On the contrary, several clinical trials have shown the therapeutic efficacy of the drug in preventing partial and generalized seizures. 2. We performed computerized EEG monitoring in 21 patients suffering from focal and generalized epilepsy before and 4 months after addition of LTG. The anticonvulsant modified the EEG ictal events by reducing their frequency and duration. A statistically significant decrease of the interictal spikes was observed. The decrease involved mainly the spreading component of the interictal events leading to a better spatial definition of the epileptic focus. 3. In the presence of LTG, generalized tonic-clonic attacks were completely controlled, whereas partial seizures were decreased. 4. The EEG background activity was not modified by the addition of the drug. 5. Our findings suggest a specific role for LTG in the generation and propagation processes of epileptiform activity without interfering with the EEG background activity.

References

Mar 1, 1992·Seizure : the Journal of the British Epilepsy Association·T Betts
May 23, 1992·Lancet·P L Timmings, A Richens
Nov 14, 1992·Lancet·J StewartE H Reynolds
Jan 1, 1992·European Neurology·P L Timmings, A Richens
Aug 1, 1986·British Journal of Clinical Pharmacology·S JawadA Richens
May 1, 1986·Epilepsia·C D BinnieA van Wieringen
Jan 1, 1982·Electroencephalography and Clinical Neurophysiology·T GasserJ Möcks
Mar 1, 1995·Seizure : the Journal of the British Epilepsy Association·J P Leach, M J Brodie
May 1, 1993·The International Journal of Neuroscience·M G MarcianiG Bernardi
Feb 13, 1993·Lancet·C P PanayiotopoulosR O Robinson
May 8, 1993·Lancet·F PisaniA Richens
Mar 1, 1994·Epilepsia·E SchlumbergerO Dulac
May 1, 1993·Journal of Neurology, Neurosurgery, and Psychiatry·G J SchapelG Davies
Jun 20, 1996·European Journal of Pharmacology·A StefaniG Bernardi

❮ Previous
Next ❯

Citations

Feb 3, 2000·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·M DahlinE Knutsson
Aug 6, 2003·Epilepsy & Behavior : E&B·Cigdem Inan Akman, Gregory L Holmes
Jun 26, 2003·Epilepsia·Albert P AldenkampRianne Reijs
Mar 10, 2007·Parkinsonism & Related Disorders·J N CavinessC H Adler
Jul 12, 2013·Epilepsy Research and Treatment·Filippo Sean GiorgiEnrica Bonanni
Oct 20, 2004·Pediatrics International : Official Journal of the Japan Pediatric Society·Bruria Ben-ZeevTally Lerman-Sagie
Jul 15, 2015·Expert Review of Neurotherapeutics·Melania GuidaFilippo Sean Giorgi
Oct 20, 1998·The International Journal of Neuroscience·M G MarcianiD Mattia
Jan 9, 2019·Frontiers in Neurology·Giovanni PellegrinoGiovanni Assenza
Jan 23, 2021·CNS Drugs·Adam Strzelczyk, Susanne Schubert-Bast
Dec 3, 2014·Journal of Affective Disorders·Cumhur TasElliot C Brown

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.