Effect of landiolol hydrochloride on suxamethonium-induced neuromuscular block

Journal of Anesthesia
T SuzukiS Ogawa

Abstract

The aim of this study was to examine the effect of landiolol hydrochloride, an ultrashort-acting beta(1)-blocker, on suxamethonium-induced neuromuscular block. Thirty patients were randomly allocated to receive a loading dose of landiolol, 0.125 mg x kg(-1) x min(-1) for 1 min, followed by an infusion at 0.04 mg x kg(-1) x min(-1), or placebo. Twenty minutes after the infusion of landiolol or placebo, suxamethonium 1 mg x kg(-1) was administered during propofolfentanyl-nitrous oxide anesthesia. Neuromuscular block was monitored by train-of-four (TOF) responses of the adductor pollicis muscle, applying acceleromyographic stimuli to the ulnar nerve. The onset of neuromuscular block did not differ between the groups. The time from administration of suxamethonium to spontaneous recovery to the first twitch of TOF (T1) of control was significantly longer in the landiolol group (mean [SD]; 12.2 [2.5] min), when compared with the control group (9.8 [2.6] min). However, the TOF ratios measured when the T1 had spontaneously recovered to 10%, 25%, 50%, 75%, 90%, and 100% of control was comparable between the groups. Landiolol delayed recovery from suxamethonium-induced paralysis. However, the interaction between the drugs seemed to be sm...Continue Reading

References

Nov 1, 1977·British Journal of Anaesthesia·H SuzukiK Tai
Jun 1, 1992·Chemical & Pharmaceutical Bulletin·S IguchiM Kawamura
Jul 1, 1992·British Journal of Anaesthesia·L E VanlinthoutL H Booij
May 1, 1986·Journal of Clinical Pharmacology·V S MurthyA R Laddu
Dec 1, 1967·British Journal of Anaesthesia·L Wislicki, I Rosenblum
Nov 1, 1984·Canadian Anaesthetists' Society Journal·A M SafwatD C Bilton
Jul 1, 1983·Anesthesia and Analgesia·V NigrovicJ T Martin
Mar 21, 2002·JAMA : the Journal of the American Medical Association·Andrew D Auerbach, Lee Goldman
Apr 1, 1965·British Journal of Pharmacology and Chemotherapy·A MORALES AGUILERA, E M VAUGHANWILLIAMS
Mar 9, 2005·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Akinori YamazakiYoshio Hatano
Nov 2, 2005·Journal of Anesthesia·Toru GoyagiToshiaki Nishikawa

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