Effect of landiolol hydrochloride on suxamethonium-induced neuromuscular block

Journal of Anesthesia
T SuzukiS Ogawa


The aim of this study was to examine the effect of landiolol hydrochloride, an ultrashort-acting beta(1)-blocker, on suxamethonium-induced neuromuscular block. Thirty patients were randomly allocated to receive a loading dose of landiolol, 0.125 mg x kg(-1) x min(-1) for 1 min, followed by an infusion at 0.04 mg x kg(-1) x min(-1), or placebo. Twenty minutes after the infusion of landiolol or placebo, suxamethonium 1 mg x kg(-1) was administered during propofolfentanyl-nitrous oxide anesthesia. Neuromuscular block was monitored by train-of-four (TOF) responses of the adductor pollicis muscle, applying acceleromyographic stimuli to the ulnar nerve. The onset of neuromuscular block did not differ between the groups. The time from administration of suxamethonium to spontaneous recovery to the first twitch of TOF (T1) of control was significantly longer in the landiolol group (mean [SD]; 12.2 [2.5] min), when compared with the control group (9.8 [2.6] min). However, the TOF ratios measured when the T1 had spontaneously recovered to 10%, 25%, 50%, 75%, 90%, and 100% of control was comparable between the groups. Landiolol delayed recovery from suxamethonium-induced paralysis. However, the interaction between the drugs seemed to be sm...Continue Reading


Nov 1, 1977·British Journal of Anaesthesia·H SuzukiK Tai
Jun 1, 1992·Chemical & Pharmaceutical Bulletin·S IguchiM Kawamura
Jul 1, 1992·British Journal of Anaesthesia·L E VanlinthoutL H Booij
May 1, 1986·Journal of Clinical Pharmacology·V S MurthyA R Laddu
Dec 1, 1967·British Journal of Anaesthesia·L Wislicki, I Rosenblum
Nov 1, 1984·Canadian Anaesthetists' Society Journal·A M SafwatD C Bilton
Jul 1, 1983·Anesthesia and Analgesia·V NigrovicJ T Martin
Mar 21, 2002·JAMA : the Journal of the American Medical Association·Andrew D Auerbach, Lee Goldman
Apr 1, 1965·British Journal of Pharmacology and Chemotherapy·A MORALES AGUILERA, E M VAUGHANWILLIAMS
Mar 9, 2005·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Akinori YamazakiYoshio Hatano
Nov 2, 2005·Journal of Anesthesia·Toru GoyagiToshiaki Nishikawa

Related Concepts

Adrenergic beta-Antagonists
Anesthesia Recovery Period
Electric Stimulation Technique
Neuromuscular Depolarizing Agents
Preanesthetic Medication
Gynecologic Surgical Procedures
Structure of Ulnar Nerve

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.