Effect of lanthanide ions on histamine secretion from rat peritoneal mast cells

British Journal of Pharmacology
F L Pearce, J R White

Abstract

1 Ions of the lanthanide series (lanthanum-lutetium) inhibit histamine release induced by allergen and anti-IgE in the presence of extracellular calcium. The inhibition is dose-dependent in the range 10(-6) to 10(-9) M and there is no marked difference in potency between the lanthanides. 2 The response to lanthanum is biphasic and higher concentrations (10(-4) M) potentiate the release. Maximal concentrations (10(-3) M) again abolish secretion. 3 The effect of concanavalin A is weakly antagonized by lanthanum but strongly inhibited by higher lanthanides. 4 Inhibition of histamine release evoked by basic agents is markedly dependent on the ionic radius of the lanthanide. In the presence of extracellular calcium, dysprosium is the most effective inhibitor. Similar results are observed with dextran. In the absence of calcium, there is a regular increase in inhibition with decreasing ionic radius. 5 Inhibition of release in the presence of calcium is immediate and does not require preincubation with the lanthanide. The antagonism due to lanthanum is competitive and the pA2 values vary with the secretagogue. In contrast, the inhibitory effect in the absence of extracellular calcium increase progressively with time. 6 These results a...Continue Reading

References

Feb 15, 1978·Biochemical Pharmacology·J H Baxter, R Adamik
Jan 1, 1979·International Archives of Allergy and Applied Immunology·M Ennis, F L Pearce
May 1, 1979·Quarterly Reviews of Biophysics·R B Martin, F S Richardson
Jul 1, 1973·British Journal of Pharmacology·J C Foreman, J L Mongar
Oct 1, 1974·Acta Pharmacologica Et Toxicologica·N Grosman, B Diamant
Dec 14, 1971·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·J Heuser, R Miledi
Jan 17, 1973·Nature: New Biology·E K MatthewsJ J Dreifuss
Mar 1, 1971·The American Journal of Physiology·F R Goodman, G B Weiss
Sep 1, 1972·The Journal of Cell Biology·G A Langer, J S Frank
Jan 1, 1980·International Archives of Allergy and Applied Immunology·M EnnisF L Pearce
Oct 1, 1980·British Journal of Pharmacology·M EnnisP M Weston
Nov 1, 1966·The Journal of General Physiology·M TakataJ W Moore
Mar 1, 1959·British Journal of Pharmacology and Chemotherapy·O ARUNLAKSHANA, H O SCHILD

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Citations

Apr 1, 1984·Agents and Actions·N Chakravarty, W J Yu
Apr 1, 1984·Agents and Actions·F L Pearce, J R White
Jan 1, 1983·Pharmacology & Therapeutics·B R Creese
Dec 22, 1999·British Journal of Pharmacology·P J BalesP D Marley
Jun 6, 2009·Critical Reviews in Immunology·Hong-Tao Ma, Michael A Beaven
Oct 23, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J W RychterA B A Kroese
Jan 1, 1985·British Journal of Clinical Pharmacology·F L Pearce
Nov 23, 1982·Biochemistry·J R White, F L Pearce

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