PMID: 2484235Nov 1, 1989Paper

Effect of latent iron deficiency on metal levels of rat brain regions

Biological Trace Element Research
A ShuklaG S Shukla

Abstract

Seven different metals (iron, copper, zinc, calcium, manganese, lead, and cadmium) were studied in eight different brain regions (cerebral cortex, cerebellum, corpus striatum, hypothalamus, hippocampus, midbrain, medulla oblongata, and pons) of weaned rats (21-d-old) maintained on an iron-deficient (18-20 mg iron/kg) diet for 8 wk. Iron was found to decrease in all the brain regions, except medulla oblongata and pons, in comparison to their respective levels in control rats, receiving an iron-sufficient (390 mg iron/kg) diet. Brain regions showed different susceptibility toward iron deficiency-induced alterations in the levels of various metals, such as zinc, was found to increase in hippocampus (19%, p less than 0.05) and midbrain (16%, p less than 0.05), copper in cerebral cortex (18%, p less than 0.05) and corpus striatum (16% p less than 0.05), calcium in corpus striatum (22%, p less than 0.01) and hypothalamus (17%, p less than 0.02), and manganese in hypothalamus (18%, p less than 0.05) only. Toxic metals lead and cadmium also increased in cerebellum (19%, p less than 0.05) and hippocampus (17%, p less than 0.05) regions, respectively. Apart from these changes, liver (64%, p less than 0.001) and brain (19%, p less than 0....Continue Reading

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Citations

Jan 1, 2003·Indian Journal of Clinical Biochemistry : IJCB·Rama Devi MittalKailash Nath Agarwal
Jul 1, 2002·Indian Journal of Clinical Biochemistry : IJCB·Rama Devi MittalKailash Nath Agarwal
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Jan 27, 2018·Indian Journal of Clinical Biochemistry : IJCB·Amit Kumar Mani TiwariSanjay Mishra

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