PMID: 3756492Aug 27, 1986Paper

Effect of lead exposure on dopaminergic receptors in rat striatum and nucleus accumbens

Brain Research
S GovoniM Trabucchi

Abstract

Haloperidol- and sulpiride-displaceable [3H]spiroperidol binding and the dopamine-inhibited adenylate cyclase were measured in rats chronically exposed to lead acetate. Haloperidol-displaceable [3H]spiroperidol binding was unmodified while sulpiride-displaceable binding was increased in striatum and decreased in nucleus accumbens. In addition, the decrease of sulpiride-displaceable binding in nucleus accumbens was paralleled by a reduced ability of bromocriptine to inhibit cAMP formation in presence of the D1 receptor antagonist SCH 23390. The results support the concept that in vivo lead treatment affects dopaminergic receptors and that the binding sites labelled by [3H]spiroperidol displaced by haloperidol may be different from those which recognize sulpiride.

References

Aug 1, 1978·European Journal of Pharmacology·M Briley, S Z Langer
Jan 11, 1979·Nature·J W Kebabian, D B Calne
May 1, 1975·Neuropharmacology·E K Silbergeld, A M Goldberg
Feb 26, 1985·European Journal of Pharmacology·C MissaleP Spano
May 1, 1980·Pharmacological Research Communications·S GovoniM Trabucchi
Dec 1, 1980·Archives of Toxicology·S C Bondy, A K Agrawal
Jul 15, 1983·European Journal of Pharmacology·J Hyttel
Sep 1, 1980·Analytical Biochemistry·P J Munson, D Rodbard
Apr 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·S J List, P Seeman
May 1, 1981·Science·H Zenick, M Goldsmith

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Citations

Jun 1, 1988·The Science of the Total Environment·R A RiusM Trabucchi
Dec 30, 1988·Toxicology·R M MorescoM Trabucchi
Sep 1, 1986·Toxicology Letters·L LucchiM Trabucchi
Jan 21, 2000·Neurotoxicology and Teratology·R L CommissarisD K Pitts
Jan 6, 2011·Environmental Health Perspectives·Ananya RoyKalpana Balakrishnan
May 5, 2009·Journal of Endocrinological Investigation·K K DoumouchtsisD N Perrea
Jul 1, 1989·Biological Trace Element Research·L AlessioS Lombardi
May 31, 2012·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Simona CatalaniPietro Apostoli

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