Effect of Left Ventricular Outflow Tract Obstruction on Left Atrial Mechanics in Hypertrophic Cardiomyopathy

BioMed Research International
Lynne K WilliamsHarry Rakowski

Abstract

Left atrial (LA) volumes are known to be increased in hypertrophic cardiomyopathy (HCM) and are a predictor of adverse outcome. In addition, LA function is impaired and is presumed to be due to left ventricular (LV) diastolic dysfunction as a result of hypertrophy and myocardial fibrosis. In the current study, we assess the incremental effect of outflow tract obstruction (and concomitant mitral regurgitation) on LA function as assessed by LA strain. Patients with HCM (50 obstructive, 50 nonobstructive) were compared to 50 normal controls. A subset of obstructive patients who had undergone septal myectomy was also studied. Utilising feature-tracking software applied to cardiovascular magnetic resonance images, LA volumes and functional parameters were calculated. LA volumes were significantly elevated and LA ejection fraction and strain were significantly reduced in patients with HCM compared with controls and were significantly more affected in patients with obstruction. LA volumes and function were significantly improved after septal myectomy. LVOT obstruction and mitral regurgitation appear to further impair LA mechanics. Septal myectomy results in a significant reduction in LA volumes, paralleled by an improvement in function.

References

Oct 15, 1991·The American Journal of Cardiology·H SanadaR Takeda
Mar 23, 1989·The New England Journal of Medicine·J A WagnerS E Epstein
Jan 1, 1993·British Heart Journal·H SanadaR Takeda
Jan 12, 2008·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Shemy CarassoHarry Rakowski
Feb 4, 2009·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Sherif F NaguehArturo Evangelista
Nov 3, 2009·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Woo-In YangJong-Won Ha
Feb 16, 2010·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Roberto M SaraivaAllan L Klein
Aug 27, 2010·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Monica RoşcaCarmen Ginghină
Jan 24, 2012·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Hirohiko MotokiAllan L Klein
Sep 10, 2014·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Johannes Tammo KowallickAndreas Schuster

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Citations

Mar 5, 2020·Cardiovascular Engineering and Technology·Dylan GoodeHadi Mohammadi
Feb 2, 2019·The International Journal of Cardiovascular Imaging·Rocio HinojarCovadonga Fernández-Golfín
Nov 7, 2018·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Shuang LengLiang Zhong
Jun 9, 2018·European Radiology·Łukasz MazurkiewiczGrażyna Brzezińska-Rajszys
Sep 25, 2021·Physiological Reports·Lisa A GottliebLukas Rc Dekker
Oct 13, 2021·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Betty RamanStefan Neubauer
Oct 30, 2021·The International Journal of Cardiovascular Imaging·Ibrahim MaraiShemy Carasso

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Software Mentioned

QMassMR
MedCalc
VVI
SAS

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