PMID: 8425209Jan 1, 1993Paper

Effect of lentinan on macrophage cytotoxicity against metastatic tumor cells

Cancer Immunology, Immunotherapy : CII
A LadányiK Lapis

Abstract

We studied the effect of lentinan, a fungal polysaccharide immunomodulator, on mouse peritoneal macrophages. The i.p. treatment of mice with 10 mg/kg lentinan affected the number, plastic-adherence, and endogen peroxidase activity of peritoneal cells. The cytotoxicity of lentinan-stimulated peritoneal macrophages was determined against several murine and human metastatic tumor targets: Lewis lung carcinoma (LLT) and two human melanomas, and was found to be significantly higher than that of the macrophages from control animals. However, the highly metastatic variant of LLT (LLT-HH) was resistant to the cytolytic effect of resident and lentinan-activated macrophages as well, indicating that the stimulation for cytotoxicity depends not only on the functional activity of the effector but also on the sensitivity of the target.

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Citations

Jun 1, 1996·International Journal of Immunopharmacology·C KerékgyártóJ Fachet
May 16, 2002·International Immunopharmacology·Patrícia Ma Stuelp-CampeloMarcello Iacomini
May 25, 2013·Journal of Clinical Biochemistry and Nutrition·Masashi Mizuno, Yosuke Nishitani
May 12, 2009·Journal of Oleo Science·Ryo FukasawaSetsuko Hara
Jan 23, 2010·International Immunopharmacology·Xiaoyu ChenPeter Chi Keung Cheung
Jun 26, 2007·Mycological Research·Jiezhong Chen, Robert Seviour
Aug 22, 2006·International Immunopharmacology·Amit GuptaG N Qazi
Jan 24, 2006·International Immunopharmacology·Igor A Schepetkin, Mark T Quinn
Aug 2, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Chen-Xiao Zhang, Zi-Ru Dai
Oct 16, 2004·Expert Review of Anti-infective Therapy·Oliver KayserAlbrecht F Kiderlen
Sep 9, 1999·The American Journal of Clinical Nutrition·W J Craig
May 30, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Cui ZhouHui-Lian Che
May 15, 2018·Frontiers in Immunology·Giorgio CamilliJessica Quintin
May 29, 1997·International Journal of Cancer. Journal International Du Cancer·J TóváriJ Tímár
Apr 4, 2021·Journal of Fungi·Vaclav VetvickaTatiana A Korolenko
Jul 17, 2009·The Journal of Physical Chemistry. B·Xiaohua WangYanwei Ding
Nov 24, 1999·Journal of Agricultural and Food Chemistry·K MinatoH Tsuchida

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