PMID: 7012047Dec 15, 1980Paper

Effect of lentinan on the production of migration inhibitory factor induced by syngeneic tumor in mice

International Journal of Cancer. Journal International Du Cancer
J ZákányJ Fachet

Abstract

Attempts were made to reveal the mechanism of the inhibitory effect of lentinan on methylcholanthrene-induced transplantable fibrosarcoma (A/Ph.MC.SI) isografts. Since the involvement of a delayed-type hypersensitivity response can be supposed to operate against this syngeneic tumor, the enlargement of regional lymph nodes, the DNA synthesis activity and the migration inhibitory factor producing capacity of the regional lymph-node cells were studied in the control and lentinan-treated, tumor-bearing mice at different times after tumor implantation. The only parameter affected until the first sign of tumor inhibition on the 8th day was the MIF-producing capacity. Regional lymph-node cells in the lentinan-treated mice showed a peak response at this time while practically no MIF was produced by cells of non-treated mice. The early phase of the developing anti-tumor reaction (enlargement of and proliferation in the lymph nodes) was initiated in all recipients but only some of them could reject the tumor in the non-treated animals that rejected the tumors in all cases. It can be supposed that a tumor-induced immunosuppression emerges in the tumor-bearers and can be overcome by lentinan treatment, most likely through enhancement of t...Continue Reading

References

Jan 1, 1975·Advances in Immunology·A J Crowle
Jul 1, 1979·Cellular Immunology·A TagliabueJ L McCoy
May 10, 1979·Journal of Immunological Methods·R A AllardyceR J Stewart
Apr 1, 1977·Cellular Immunology·M W BurkC F McKhann
May 1, 1975·The Journal of Experimental Medicine·C C StewartC Adles
Mar 15, 1980·International Journal of Cancer. Journal International Du Cancer·J ZákányJ Fachet

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Citations

Jan 1, 1984·International Journal of Immunopharmacology·Y Y MaedaM Rokutanda
Jan 1, 1991·International Journal of Immunopharmacology·Y Y MaedaH Yonekawa

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