PMID: 6160202Jan 1, 1980Paper

Effect of lesions of raphe nuclei on the activity of catecholaminergic and serotonergic neurones in various brain regions of the rat in vivo

Journal of Neural Transmission
H Rommelspacher, S Strauss

Abstract

The dorsal raphe nucleus (DRN), the median raphe nucleus (MRN) and the B9 cell groups were lesioned separately. Then, the concentrations of 5-hydroxytryptamine (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), dopamine (DA), 5-hydroxytryptophan (5-HTP) and dopa were measured in various brain regions. The levels of the two latter compounds presumably reflect the activity of serotonergic and catecholaminergic neurones respectively under the experimental conditions. The findings suggest close functional interrelationships between the two types of neurones. Lesions of cell bodies in the DRN cause decreased activity of catecholaminergic neurones in the striatum, the brainstem, the hippocampus, and the hypothalamus. Lesions of the MRN cause increased activity of catecholaminergic mechanisms in the hypothalamus which may be explained by a functional disinhibition after destruction of the MRN. The other brain regions investigated are not affected. Lesions of the B9 cell group elicit increased activity of catecholaminergic neurones in the brainstem and hippocampus.

References

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Citations

Mar 1, 1992·Pharmacology, Biochemistry, and Behavior·D Wirtshafter, R Trifunovic
Jan 1, 1983·Neurochemistry International·G AlmazanT L Sourkes
Jul 1, 1988·Pharmacology, Biochemistry, and Behavior·D WirtshafterK E Asin
Aug 22, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Michael BehenOtto Muzik
Oct 29, 2005·The Journal of Comparative Neurology·Thomas Jhou

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