Effect of leucine metabolite beta-hydroxy-beta-methylbutyrate on muscle metabolism during resistance-exercise training

Journal of Applied Physiology
S NissenN Abumrad

Abstract

The effects of dietary supplementation with the leucine metabolite beta-hydroxy-beta-methylbutyrate (HMB) were studied in two experiments. In study 1, subjects (n = 41) were randomized among three levels of HMB supplementation (0, 1.5 or 3.0 g HMB/day) and two protein levels (normal, 117 g/day, or high, 175 g/day) and weight lifted for 1.5 h 3 days/wk for 3 wk. In study 2, subjects (n = 28) were fed either 0 or 3.0 g HMB/day and weight lifted for 2-3 h 6 days/wk for 7 wk. In study 1, HMB significantly decreased the exercise-induced rise in muscle proteolysis as measured by urine 3-methylhistidine during the first 2 wk of exercise (linear decrease, P < 0.04). Plasma creatine phosphokinase was also decreased with HMB supplementation (week 3, linear decrease, P < 0.05). Weight lifted was increased by HMB supplementation when compared with the unsupplemented subjects during each week of the study (linear increase, P < 0.02). In study 2, fat-free mass was significantly increased in HMB-supplemented subjects compared with the unsupplemented group at 2 and 4-6 wk of the study (P < 0.05). In conclusion, supplementation with either 1.5 or 3 g HMB/day can partly prevent exercise-induced proteolysis and/or muscle damage and result in larg...Continue Reading

References

Nov 1, 1992·Journal of Applied Physiology·M A TarnopolskyH P Schwarcz
Sep 1, 1989·Proceedings of the Society for Experimental Biology and Medicine·R N Reusch
Dec 1, 1986·The American Journal of Clinical Nutrition·C AusselJ Giboudeau
Jul 1, 1984·The Journal of Nutrition·S O Hong, D K Layman
Feb 1, 1983·Metabolism: Clinical and Experimental·P J Sabourin, L L Bieber

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Citations

Dec 29, 2000·Medicine and Science in Sports and Exercise·P M GallagherS W Trappe
Nov 16, 2002·Journal of Applied Physiology·Steven L Nissen, Rick L Sharp
Apr 6, 2004·Medicine and Science in Sports and Exercise·Britni N Buford, Alexander J Koch
Jan 12, 2007·The Journal of Trauma·Deborah A KuhlsJohn J Fildes
Nov 15, 2011·European Journal of Applied Physiology·Carlos Hermano da Justa PinheiroRui Curi
May 11, 2011·Journal of Strength and Conditioning Research·Naji N Abumrad, John A Rathmacher
Sep 21, 2012·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Cagdas YavasOzlem Ata
Feb 5, 2013·Journal of the International Society of Sports Nutrition·Jacob M WilsonJose Antonio
Nov 28, 2013·Critical Reviews in Food Science and Nutrition·Feby LuckoseKolpe Radhakrishna
Jul 17, 2014·Journal of Strength and Conditioning Research·Frank M DiLorenzoJanet W Rankin
Sep 17, 2014·Journal of Strength and Conditioning Research·Benjamin WaxJoseph Sperlak
Mar 21, 2015·International Journal of Endocrinology·Jeremy R TownsendJeffrey R Stout
Mar 12, 2016·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Osman EkinciŞevki Erdem
Mar 24, 2018·Journal of Strength and Conditioning Research·John A Rathmacher
Mar 14, 2020·Journal of the International Society of Sports Nutrition·Alexander C StahnElmarie Terblanche
Dec 29, 2000·Medicine and Science in Sports and Exercise·P M GallagherS W Trappe
Sep 28, 2000·Journal of Applied Physiology·A E KnitterR Sharp
Oct 9, 2002·Medicine and Science in Sports and Exercise·Cathy M FomousPaul M Coates
Mar 31, 2004·The American Journal of Clinical Nutrition·Max H Pittler, Edzard Ernst
Aug 23, 2002·Annals of Surgery·Jeremy Z WilliamsAdrian Barbul
May 17, 2003·Medicine and Science in Sports and Exercise·Janet L VierckMichael V Dodson
Feb 21, 2008·Journal of the International Society of Sports Nutrition·James P WhiteLynn B Panton
Feb 6, 2010·Critical Care Medicine·Lindsay-Rae B WeitzelPaul E Wischmeyer
Sep 2, 2006·HIV Medicine·W D DudgeonG A Hand
May 1, 2009·Molecular and Cellular Biochemistry·Steven T Russell, Michael J Tisdale
May 27, 2008·Journal of the International Society of Sports Nutrition·Melvin Williams
Jan 15, 2010·Journal of Strength and Conditioning Research·David NunanKen A van Someren

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