PMID: 9160411Aug 1, 1996Paper

Effect of leukotriene D4 on ciliary activity in human, guinea-pig and rat respiratory mucosa

Pulmonary Pharmacology
S JokiJ Nuutinen

Abstract

Leukotriene D4 (LTD4) is a potent bronchoconstrictor and inflammatory mediator in asthma. Data concerning the effects of LTD4 on ciliary function in the respiratory tract are sparse and contradictory. The purpose of the present study was to clarify the effects of LTD4 on mucociliary activity using the tracheal mucosa of two laboratory animal species, guinea-pig and rat, as well as human nasal mucosa. The ciliary beat frequency (CBF) was measured photoelectrically and determined by Fast Fourier Transform computer analysis. Additionally the structure of ciliated epithelia of guinea-pig trachea after LTD4-immersion was investigated using a scanning electron microscope (SEM). In all tissues, LTD4 increased CBF showing a bell-shaped dose-response curve. The maximum effect was 75 +/- 30% in guinea-pig at 10(-9) mol/l, 119 +/- 49% in rat at 10(-7) mol/l, and 86 +/- 28% at 10(-6) mol/l in human tissue. In guinea-pig tracheal mucosa, there was an indication of an increase in the amount of mucus and disorientation of cilia were seen by SEM after immersion in LTD4. These findings suggest that LTD4 stimulates ciliary activity, but impairs the orientation of cilia.

Citations

Jul 19, 2005·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Ryan C CmejrekSteven M Houser
Dec 17, 2014·American Journal of Rhinology & Allergy·Alan D Workman, Noam A Cohen
Jul 9, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H ShirasakiT Himi
May 13, 2004·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Michael GutmanSteven M Houser
Nov 12, 2014·Annual Review of Physiology·Ann E TilleyRonald G Crystal
May 22, 2020·Frontiers in Pharmacology·Marta JoskovaSona Franova
Mar 20, 2008·Expert Opinion on Therapeutic Targets·Hideaki Shirasaki
Aug 3, 2010·The Journal of Allergy and Clinical Immunology·Biju ThomasChristopher O'Callaghan
May 16, 2019·International Archives of Allergy and Immunology·Marek MikolajczykZbigniew Baj

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