PMID: 6968971Jan 1, 1980Paper

Effect of levamisole on immunological parameters in patients with systemic lupus erythematosus

Scandinavian Journal of Rheumatology
O ScherakG Kolarz

Abstract

Parameters of cell-mediated and humoral immunity were examined in 8 patients with clinically inactive SLE undergoing levamisole treatment. Lymphocyte transformation with PHA and PMW was temporarily increased in the first month of therapy; at the same time absolute numbers of peripheral blood lymphocytes, T cells and B cells increased slightly. However, these differences were not significant statistically. In 1 patient with a diminished percentage of T cells and an increased percentage of B cells, levamisole induced normalization. Antibodies to DNA decreased in 6 patients, while titres of ANA decreased only in one patient. Serum levels of C1q and C3 increased in 7 and 3 patients, respectively. Four patients were treated with levamisole for 12 months, during which time there was neither clinical exacerbation nor deterioration of renal function and the concomitant corticosteroid therapy could be reduced.

References

Feb 21, 1976·Lancet·E C HuskissonD A Willoughby
Jul 30, 1977·Lancet·K M GoebelF Neurath
Mar 4, 1977·Annals of the New York Academy of Sciences·J W HaddenE M Hadden
Feb 1, 1976·Cellular Immunology·M E WhitcombS R Cooperband
Nov 1, 1976·Clinical Immunology and Immunopathology·M E Schmidt, S D Douglas
Dec 12, 1975·Die Medizinische Welt·E M Lemmel
Sep 1, 1972·Arthritis and Rheumatism·A S Cohen, J J Canoso
Oct 1, 1973·British Journal of Haematology·G R Hughes
Jan 1, 1972·Scandinavian Journal of Immunology·S S Froland, J B Natvig
Aug 16, 1973·The New England Journal of Medicine·D TripodiJ Brugmans

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Citations

Jan 1, 1981·The Journal of Clinical Investigation·R D SontheimerJ N Gilliam

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