Effect of licorice on PTH levels in healthy women

Steroids
Mee Jung MattarelloDecio Armanini

Abstract

Licorice has been considered a medicinal plant for thousands of years. Its most common side effect is hypokalemic hypertension, which is secondary to a block of 11beta-hydroxysteroid dehydrogenase type 2 at the level of the kidney, leading to an enhanced mineralocorticoid effect of cortisol. This effect is due to glycyrrhetinic acid, which is the main constituent of the root, but other components are also present, including isoflavans, which have estrogen-like activity, and are thus involved in the modulation of bone metabolism. We investigated nine healthy women 22-26 years old, in the luteal phase of the cycle. They were given 3.5 g of a commercial preparation of licorice (containing 7.6%, w/w of glycyrrhizic acid) daily for 2 months. Plasma renin activity (PRA), aldosterone, cortisol, serum parathyroid hormone (PTH), 1,25-dihydroxy Vitamin D (1,25OHD), 25-hydroxycholecalciferol (25OHD), estradiol, FHS, LH, alkaline phosphatase (ALP), calcium, phosphate and creatinine, urinary calcium and phosphate and mineralometry were measured. PTH, 25OHD and urinary calcium increased significantly from baseline values after 2 months of therapy, while 1,25OHD and ALP did not change during treatment. All these parameters returned to pretrea...Continue Reading

References

Mar 1, 1989·Endocrinology·C H KasperkD J Baylink
Apr 1, 1988·Endocrinologia Japonica·K Sakamoto, K Wakabayashi
Mar 1, 1988·The Journal of Clinical Endocrinology and Metabolism·B DuarteS C Kukreja
Nov 1, 1983·Clinical Endocrinology·D ArmaniniJ W Funder
Sep 1, 1999·Clinical Endocrinology·R M Francis
Oct 9, 1999·The New England Journal of Medicine·D ArmaniniM Palermo
Oct 10, 2002·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·D ArmaniniM Palermo
Sep 1, 2004·The Journal of Steroid Biochemistry and Molecular Biology·Dalia SomjenSnait Tamir
Sep 1, 2004·Maturitas·Michael J Reed, Helenius J Kloosterboer
Dec 8, 2004·Steroids·Decio ArmaniniMario Palermo

❮ Previous
Next ❯

Citations

Jan 5, 2007·Internal Medicine·Toshiro SugimotoAtsunori Kashiwagi
Jun 3, 2010·Clinical Science·Piotr SobieszczykJoshua A Beckman
Apr 22, 2016·The Journal of Clinical Hypertension·Decio ArmaniniChiara Sabbadin
Jun 3, 2016·The Journal of Clinical Hypertension·John M Apostolakos, Laurie C Caines
Nov 28, 2012·Therapeutic Advances in Endocrinology and Metabolism·Hesham R OmarEnrico M Camporesi
Oct 17, 2019·Foods·Mikkel R DeutchMarcus Krüger
Aug 6, 2021·Therapeutic Advances in Psychopharmacology·Rae F BellJari Yli-Kauhaluoma
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.