PMID: 590313Dec 2, 1977

Effect of lidocaine on the absorption, disposition and tolerance of intramuscularly administered cefoxitin

European Journal of Clinical Pharmacology
P F SonnevilleC M Martin

Abstract

The use of lidocaine HCL solution at concentrations of 0.5 and 1.0% to reconstitute sodium cefoxitin relieves the pain associated with intramuscular injections of the antibiotic. Cefoxitin absorption by the intramuscular route is initially rapid and is virtually complete. Peak serum concentrations, corresponding to about one-half those of a comparable intravenous infusion, are achieved in 30 min. Continuing absorption tends to maintain higher serum concentrations for longer times. Renal clearance and serum half-life of cefoxitin do not appear to be affected by lidocaine at its effective anaesthetic concentrations.

References

Jul 15, 1977·Clinica Chimica Acta; International Journal of Clinical Chemistry·J S Wold, S A Turnipseed
Mar 22, 1976·European Journal of Clinical Pharmacology·P F SonnevilleC M Martin
Dec 1, 1974·Journal of Pharmacokinetics and Biopharmaceutics·A E TillK C Kwan
Jan 1, 1974·Antimicrobial Agents and Chemotherapy·H R OnishiE O Stapley
Oct 1, 1972·Antimicrobial Agents and Chemotherapy·A K MillerD Hendlin
Oct 1, 1972·Antimicrobial Agents and Chemotherapy·J P PhairJ S Tan
Sep 1, 1973·Journal of Pharmaceutical Sciences·K C Kwan, A E Till
Jan 1, 1974·Antimicrobial Agents and Chemotherapy·H Wallick, D Hendlin
Jan 1, 1974·The Journal of Antibiotics·J M Hamilton-MillerW Brumfitt
Jun 1, 1968·Journal of Pharmaceutical Sciences·J C Loo, S Riegelman
Nov 1, 1995·Antimicrobial Agents and Chemotherapy·S RadulovicA F Azad
Sep 1, 1956·Annual Report of the Council·D C BRIDGES
Sep 1, 1974·Antimicrobial Agents and Chemotherapy·W BrumfittJ N Gilchrist
Sep 1, 1974·Antimicrobial Agents and Chemotherapy·R C MoelleringL J Kunz

Citations

Dec 1, 1984·European Journal of Clinical Microbiology·D KunimotoA R Ronald
Dec 1, 1980·Journal of Pharmacological Methods·E CelozziA K Miller
Nov 1, 1981·Journal of Clinical Pharmacology·M DuboisA Dresse
Jan 1, 1984·European Archives of Psychiatry and Neurological Sciences·M L RaoG Huber
Aug 4, 2020·Journal of Veterinary Pharmacology and Therapeutics·Ana P CostaKatrina L Mealey

Related Concepts

Process of Absorption
Mefoxin
Cephalosporanic Acids
Drug Interactions
Half-Life
Intramuscular Injection
Lidocaine Monohydrochloride, Monohydrate

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