Effect of lidocaine on the early inward transient current in sheep cardiac Purkinje fibers.

Circulation Research
F M Weld, J T Bigger

Abstract

We used two experimental techniques to study the effect of lidocaine hydrochloride on the early inward transient (sodium) current as it is reflected by the maximum rate of change of action potential phase 0 (Vmax). We assessed the effect of lidocaine on Vmax as Purkinje fibers were slowly depolarized by increasing the extracellular potassium concentration from 4.0 to 16.0 mM; these voltage-dependent effects were compared with lidocaine's effect on membrane responsiveness (which measures both the time and the voltage dependence of Vmax). We also used a voltage clamp technique to establish the effect of lidocaine on the voltage dependence of Vmax by measuring Vmax 800-1000 msec after transmembrane voltage (Vm) had been changed in small steps. We studied the effect of lidocaine on the time course of early inward transient current reactivation by depolarizing the membrane to -25 +/- 5 mv for 100 msec to inactivate this current, clamping Vm to a repolarized test voltage for various periods, and then measuring phase 0 Vmax of action potentials elicited immediately after termination of the voltage clamp. We showed that lidocaine at 5 mg/liter, but not a 1 mg/liter, shifted the steady-state Vmax- Vm relationship to a more negative posi...Continue Reading

References

Jan 1, 1971·Naunyn-Schmiedebergs Archiv Für Pharmakologie·P Heistracher
Jan 1, 1971·Naunyn-Schmiedebergs Archiv Für Pharmakologie·H TritthartA Fleckenstein
Aug 1, 1974·The Journal of Physiology·L S Gettes, H Reuter
Jul 1, 1973·The Journal of General Physiology·G R Strichartz
Jan 1, 1973·Progress in Biophysics and Molecular Biology·H Reuter
Sep 1, 1972·The Journal of Clinical Investigation·M F Arnsdorf, J T Bigger
Apr 1, 1973·Journal of Applied Physiology·R S AronsonB F Hoffman
Jul 1, 1973·American Heart Journal·J WittigA G Wallace
Nov 1, 1973·The Journal of Physiology·H A Fozzard, M Hiraoka
Jan 1, 1971·Annual Review of Physiology·E A Johnson, M Lieberman
Jan 1, 1971·Pflügers Archiv : European journal of physiology·H G HaasM Tarr
Jan 1, 1968·Pflügers Archiv für die gesamte Physiologie des Menschen und der Tiere·O RougierR Stämpfli
Jan 1, 1970·The Journal of Clinical Investigation·J T Bigger, W J Mandel
Apr 1, 1970·The Journal of General Physiology·W H Freygang, W Trautwein
Jan 1, 1970·Pflügers Archiv : European journal of physiology·J Dudel, R Rüdel
Jan 1, 1966·The Journal of Physiology·H A Fozzard
Nov 1, 1952·The Journal of Physiology·S WEIDMANN
Jun 9, 1964·Pflügers Archiv für die gesamte Physiologie des Menschen und der Tiere·K A DECKW TRAUTWEIN
Mar 3, 1949·The Journal of Physiology·A L HODGKIN, B KATZ

❮ Previous
Next ❯

Citations

Feb 1, 1984·Pflügers Archiv : European journal of physiology·G A Gintant, B F Hoffman
Jul 1, 1982·Pflügers Archiv : European journal of physiology·T Saikawa, E Carmeliet
May 1, 1979·European Journal of Pharmacology·H M EinwächterJ Herb
Dec 9, 1983·European Journal of Pharmacology·K HewettM R Rosen
May 1, 1977·Progress in Cardiovascular Diseases·M F Arnsdorf
Jan 1, 1978·Progress in Biophysics and Molecular Biology·G W Beeler, J A McGuigan
Jan 1, 1980·Progress in Biophysics and Molecular Biology·M R Boyett, B R Jewell
May 1, 1983·The Journal of General Physiology·B P BeanR W Tsien
Apr 1, 1978·The American Journal of Cardiology·E N MooreR A Moller
May 1, 1978·The American Journal of Cardiology·R LazzaraB J Scherlag
Apr 11, 1992·American Heart Journal·A O Grant
Aug 1, 1977·The American Journal of Cardiology·V AravindakshanL S Gettes
Mar 1, 1982·Pacing and Clinical Electrophysiology : PACE·J F Spear, E N Moore

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.