PMID: 16617359Apr 18, 2006Paper

Effect of lidocaine on the impairment of learning and memory function and central cholinergic system after transient global cerebral ischemia in mice

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
Ping-ping SongPing-ping Zuo

Abstract

To evaluate the effects of lidocaine on the impairments of learning and memorial function and central cholinergic system after transient global cerebral ischemia in mice of different apolipoprotein E genotypes. Transient global ischemia was induced by bilateral common carotid arteries occlusion (BCCAO) for 17 minutes. Healthy male C57BL/6J wild-type mice (C57 mice) and apolipoprotein E knockout mice (ApoE mice) were randomly divided into six groups: C57 control group (sham operation, neither BCCAO was performed nor pharmacologic intervention was given), C57 ischemia group (BCCAO for 17 minutes was performed and normal saline was given intraperitoneally), C57 lidocaine group (BCCAO for 17 minutes was performed and lidocaine was given intraperitoneally), ApoE control group (the same procedure as that of C57 control group), ApoE ischemia group (the same procedure as that of C57 ischemia group), ApoE lidocaine group (the same procedure as that of C57 lidocaine group). The mice were allowed to recover for 7 days. Morris water maze test were performed from the 8th postoperative day. Mice were tested four times daily for 5 consecutive days. The latency periods were recorded and the percentages of effective search strategies were calcu...Continue Reading

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

Related Papers

Zhonghua wai ke za zhi [Chinese journal of surgery]
Cheng-hong PengXian-chuan Jiang
International Journal of Radiation Oncology, Biology, Physics
Siddhartha LaskarKetayun A Dinshaw
Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
Patcharajiree Pak-artKris Chatamra
© 2022 Meta ULC. All rights reserved