Effect of lidocaine on the safety of postoperative skin reconstruction after malignant melanoma resection

Experimental and Therapeutic Medicine
Kaimei XuYanbing Wang

Abstract

Malignant melanoma is a type of skin cancer with high morbidity and mortality. Therapeutic strategies should be individualized in order to increase the survival rate. The aim of this study was to assess the effect of lidocaine on skin healing and immune function after operation of patients with melanoma. Sixty patients with melanoma were selected from those treated in Bishan Hospital between August 2014 and August 2016. The patients were randomly divided into lidocaine group and control group. Lidocaine group was locally treated with an intradermic injection of 2% lidocaine solution in dose of 1.5 mg/kg and the control group received the same quantity of saline solution. In the lidocaine group, the rates of skin temperature, drug reaction, healing and infection were higher than the corresponding rates in the C group. The local application of lidocaine can promote wound healing to a certain extent, reduce pain, and promote postoperative skin reconstruction.

References

May 1, 1993·The American Journal of Emergency Medicine·P Aggarwal, J P Wali
Feb 18, 2006·Developmental Medicine and Child Neurology·Shin-ichiro HamanoYoshikatsu Eto
Oct 23, 2010·Expert Review of Molecular Diagnostics·Monica NeaguCristiana Tanase
Apr 10, 2013·The Journal of Hand Surgery·Hyuk Jin LeeGoo Hyun Baek
Feb 11, 2015·International Journal of Experimental Pathology·Corina DanciuCristina Dehelean
Apr 1, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Zhun ZhongShu-Cheng Yin
Nov 26, 2015·Journal of Cancer Research and Clinical Oncology·Roberta Colucci, Silvia Moretti
Dec 2, 2015·Oncology Letters·Yunfeng MaSenyang Lang
Jul 18, 2017·International Journal of Molecular Medicine·Seung Hwan YangGyuhwa Chung
Sep 30, 2017·Toxicology Reports·Joanna A RuszkiewiczMichael Aschner
Oct 19, 2017·International Journal of Oncology·Angela CauniiCristina Dehelean
Dec 27, 2017·Anticancer Research·Thiên-Nga Chamaraux-TranCherif Akladios

❮ Previous
Next ❯

Citations

Aug 9, 2020·Frontiers in Cell and Developmental Biology·Daipeng ZhouPeng Xu

❮ Previous
Next ❯

Methods Mentioned

BETA
surgical resection
flow cytometry
surgical stress

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.