Effect of Lifestyle Intervention on the Hormonal Profile of Frail, Obese Older Men

The Journal of Nutrition, Health & Aging
Reina Armamento-VillarealDennis T Villareal

Abstract

Obesity-associated hypogonadism is hypothesized to be due to the suppressive effect of high estradiol (from an increase in aromatase activity present in the abundant adipose tissue) on the hypothalamic-pituitary-gonadal unit resulting in low testosterone production. Although weight loss has been found to be effective in reducing estradiol and raising testosterone levels in studies of younger men, its effect in frail, obese older men is understudied. Thus, the objective of this study was to determine the effect of lifestyle intervention on hormone levels in frail, obese older men. Randomized controlled trial of lifestyle intervention in frail, obese older men (≥65 yo) for 1 year. University hospital. Forty frail, obese elderly men were randomized, for a 52-week study, to any of the following treatment groups: (1) control group, (2) diet-induced weight loss group (diet group), (3) exercise training group (exercise group), and (4) diet-induced weight loss and exercise training group (diet-exercise group). The objective was to achieve a ~10 % weight loss at 6 months and maintain this weight for an additional 6 months. Physical function was assessed by the modified physical performance testing (modified PPT). Estradiol was measured ...Continue Reading

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Citations

Aug 2, 2018·Nature Reviews. Endocrinology·John A Batsis, Dennis T Villareal
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Feb 5, 2021·Frontiers in Endocrinology·Vittoria RussoReina Armamento-Villareal
Mar 24, 2020·Sexual Medicine·Omer Faruk KirlangicSerap Gur
Jul 4, 2021·Cancer Causes & Control : CCC·Eleanor L WattsRuth C Travis

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